| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | phenotype | BEFREE | SPP1 is associated with malignant transformation in NF1-associated MPNSTs and could prove to be an important target for therapeutic intervention. | 25884485 | 2015 | ||||
|
0.090 | Biomarker | phenotype | BEFREE | Regulatory role of osteopontin in malignant transformation of endometrial cancer. | 23269624 | 2013 | ||||
|
0.090 | Biomarker | phenotype | BEFREE | In this study, we have used the bacterial two-hybrid system to isolate cDNA-encoding proteins that bind to OPN and modulate its role in malignant transformation. | 19901966 | 2010 | ||||
|
0.090 | Biomarker | phenotype | BEFREE | Osteopontin can act as an effector for a germline mutation of BRCA1 in malignant transformation of breast cancer-related cells. | 20384635 | 2010 | ||||
|
0.090 | Biomarker | phenotype | BEFREE | Extensive research has demonstrated the pivotal participation of OPN in the regulation of cell signaling which controls neoplastic and malignant transformation. | 18508515 | 2008 | ||||
|
0.090 | Biomarker | phenotype | BEFREE | In this study, we have investigated the effects of (-)-agelastatin A on OPN-mediated malignant transformation using mammary epithelial cell lines. | 18347142 | 2008 | ||||
|
0.090 | Biomarker | phenotype | BEFREE | Osteopontin (OPN) is a matricellular protein involved in tissue remodelling, cell-mediated immunity and malignant transformation. | 17493236 | 2007 | ||||
|
0.090 | Biomarker | phenotype | BEFREE | The regulation and role of osteopontin in malignant transformation and cancer. | 17113338 | 2006 | ||||
|
0.090 | AlteredExpression | phenotype | BEFREE | The results in our study support our hypothesis and suggest that the increased OPN level may be involved in the malignant transformation of prostate epithelial cells and OPN expression level is an important determinant for patient survival. | 16331611 | 2006 |