Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE The objective of the article is to evaluate KRAS and BRAF mutations as potential genetic markers for early detection of malignant transformation, we used an ultrasensitive technique to detect tissue expression of KRAS and BRAF mutations in endoscopic biopsies from 61 adult patients under follow-up after treatment for EA. 28873491 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE In melanoma, activation of the mitogen-activated protein kinase (MAPK) pathway driven by mutant BRAF or NRAS is a primary cause of malignant transformation. 27270434 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker phenotype BEFREE The expression of the nuclear and cytoplasmic forms of p16 represent two independent mechanisms, and both seemed to control proliferation in response to oncogenic stimuli, protecting the cell from malignant transformation in BRAF-mutated GISTs. 28034324 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE Our results also provide evidence that--just as BRAF V600E mutations in hyperplastic polyps and benign nevi- a mutated driver gene does not imply malignant behavior per se but may set the basis for malignant transformation. 26493284 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE As mutant BRAF alone is insufficient to drive malignant transformation in other histological cancers, it suggests that individual tumours utilise largely differing patterns of genetic somatic mutations to coalesce with BRAF V(600)E to drive pathogenesis of malignant HCLc disease. 26871591 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE This case suggests that the BRAF V600E mutation may be involved in the malignant transformation to glioblastoma. 26404554 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker phenotype BEFREE Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation. 26065894 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE The molecular profile of the adenocarcinoma showed a mutation in KRAS and wild-type BRAF, which might be associated with malignant transformation of intracranial mature teratomas. 25039399 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker phenotype BEFREE Our findings suggest that the BRAF pathway may contribute to the pathogenesis or malignant transformation of histiocytic and dendritic cell neoplasms. 24720374 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE Activation of the MAPK pathway as a result of activating mutations in BRAF is commonly seen in melanoma though it alone is not sufficient to cause malignant transformation of melanocytes. 23554059 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE In this series the presence of a BRAF- or NRAS mutation in a nevus was not associated with the risk of malignant transformation. 23861977 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE Mutation in the BRAF oncogene is a key step in malignant transformation within the methylator pathway to colorectal cancer. 22228154 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE BRAF mutations and RET or NTRK1 rearrangements were identified as causing events that drive the malignant transformation of the thyroid follicular cell. 20640859 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE In summary, these data demonstrate that a subpopulation of melanocytes possesses the ability to survive BRAF(V600E)-induced senescence, and suggest that p53 inactivation may promote malignant transformation of these cells. 19389934 2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 AlteredExpression phenotype BEFREE In vitro and in vivo models have demonstrated that overexpression of activated BRAF induces malignant transformation and aggressive tumour behaviour. 17179987 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE These findings suggest that mutations of the BRAF gene are partly involved in the malignant transformation of the endometrium. 16144912 2005
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker phenotype BEFREE BRAF encodes a RAS-regulated serine/threonine kinase that mediates the pathway for cell growth and malignant transformation. 14719068 2004
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE Our findings of a high frequency of BRAF mutations at codon 599 in benign melanocytic lesions of the skin indicate that this mutation is not sufficient by itself for malignant transformation. 14501284 2003
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker phenotype BEFREE Three BRAF mutations identified in this study are novel, altering residues important in AKT-mediated BRAF phosphorylation and suggesting that disruption of AKT-induced BRAF inhibition can play a role in malignant transformation. 12460918 2002