Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression phenotype BEFREE Moreover, activation of the c-Jun N-terminal kinase (JNK)/c-Jun pathway was involved in the malignant transformation of HPCs. miR-199a-3p was identified as a significantly upregulated microRNA in HPCs upon HBx and TGF-β1 exposure, which were shown to promote miR-199a-3p expression via c-Jun-mediated activation. 31740785 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE TGF-β1 mediated radiation-induced bystander effects (RIBE) have been linked with malignant transformation and tumorigenesis. 30423581 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE Effect of evodiamine and berberine on the interaction between DNMTs and target microRNAs during malignant transformation of the colon by TGF-β1. 28098901 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE Transforming growth factor-β1 (TGF-β1) within tumor microenvironment has a pivotal function in cancer initiation and tumorigenesis, and hence this study was to observe the malignant transformation induced by TGF-β1 in an immortalized colon epithelial cell line NCM460 for better understanding the mechanisms of colon carcinogenesis. 27401062 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE Our findings indicate that Nrf2 and TGF-β1 both contribute to malignant transformation through distinct EMT related mechanisms accounting for an invasive phenotype. 26226105 2015
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression phenotype BEFREE Tissue-pair mRNA and protein analysis reveals VEGF transcriptional up-regulation and TGFB1 down-regulation that are correlated with the malignant transformation of the endometrium, while post-transcriptional mechanisms control VEGF and TGFB1 protein. 23176363 2013
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression phenotype BEFREE In this study, we examine the role of TGF-β1-induced L1CAM expression and macrophages in malignant transformation of intestinal epithelial cells. 22349829 2013
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer. 19435915 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 GeneticVariation phenotype BEFREE Our results suggest that the TGF-[beta]1 -509T allele may have a protective role in the development of colorectal cancer, possibly consistent with its role as an inhibitor of epithelial malignant transformation. 17214746 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE Our findings provide for the first time evidence for the implication of YY1 in uterine cervix carcinogenesis and suggest that VEGF, TGF-beta1 and YY1 could be useful biomarkers of cervical malignant transformation as well as potential targets for therapeutic approaches. 17549406 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression phenotype BEFREE Our findings show that VEGF, FGF2, TGFB1 and TGFBR1 mRNA expression levels correlate with the malignant transformation of the uterine cervix. 15797633 2005
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE Animal experiments suggest that TGFbeta1 plays a biphasic role in carcinogenesis by protecting against the early formation of benign epithelial growths, but promoting malignant transformation of those growths that do develop. 15020570 2004
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE The disruption of the transforming growth factor beta1 (TGF-beta1) autocrine growth-suppressive circuit is a major and possibly early event mediating the malignant transformation of normal epithelia. 14585325 2003
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE It is suggested that TGF beta 1 may be associated with the malignant transformation of hepatocyte or the progression of HCV-associated HCC. 11242803 2000
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE The findings presented suggest that c-jun may have a role in inducing malignant transformation in RCC and a novel mechanism by which TGF-b1 may exert its anti-tumor effects, via the activation of junB. 1404666 1992
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression phenotype BEFREE Cells became partially resistant to the inhibitory effects of TGF beta 1 on cell growth and HPV early gene expression after prolonged cultivation in vitro or after malignant transformation. 2168964 1990
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype BEFREE These findings suggest that TGF beta 1 may be an in vivo modulator of HPV infection and that loss of responsiveness to this growth inhibitory signal may be involved in HPV-associated malignant transformation. 2171761 1990