Interferons (IFNs) are critical mediators of the innate defense to infection, and in this study we evaluated the contribution of a specific gene coding for IFIT2 induced by type I IFNs in a murine model of disseminated <i>Candida albicans</i> Invasive candidiasis is a frequent challenge during immunosuppression or surgical medical interventions, and <i>C. albicans</i> is a common culprit that leads to high rates of mortality.