In this study we report that GAB transfection inhibits growth and increases susceptibility towards TMZ and H₂O₂-mediated oxidative stress of two other GBM cell lines, U87MG and LN229.
In conclusion, while mechanistic relation between GAB and GATA3 expression is evident following in vitro manipulation of GBM cell line, it does not appear to be an intrinsic property of GBM nor non-tumorigenic brain tissue.
The results show that combination of negative modulation of GA isoforms arising from GLS gene with the introduction of the GLS2 gene product, GAB, may in the future provide a useful means to curb glioblastoma growth in situ.