Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Despite the fact that, due to small sample size, our results should be considered as preliminary, our study suggests that miR-34a is associated with tumor burden and can be important for health-related quality of life, functional status, and mood symptoms of glioblastoma patients. 30836600 2019
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Therefore, we set out to assess the role of hBMSC secreted exosomes, in particular those carrying microRNA-34a (miR-34a), in the development of GBM. 31332647 2019
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation. 29857516 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE Consistent to the computationally predicted miRNA-lncRNA interaction, negative correlations were observed between levels of GAS5 and miR-34a in RCC samples (r = -0.949, p < 0.001), GB (r = -0.518, p < 0.001) and HCC (r = -0.455, p = 0.013). 30289954 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE We focused on miR-34a, which is known for its key role in important oncogenic pathways and its tumor suppression ability in GBM and other cancers. 27569663 2016
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Using targeted cationic liposomes that bind to the epidermal growth factor receptor (EGFR), we delivered miR34a and/or anti-sense oligonucleotide to miR21 (ASO21) to GBM tumor cell lines, U87MG and A172, in vitro. 29345889 2016
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE Conversely, both miR-133b and miR-34a were markedly downregulated in clinical GBM specimens by qRT-PCR. 25355491 2015
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Whilst drugs directly targeting SIRT1, were potent to trigger cell death at high concentrations only, introduction of synthetic miR-34a mimics was able to induce cell death in p53 mutated medulloblastoma and glioblastoma cell lines. 25250818 2014
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Also, human GBM cells (U251) stable overexpressing mir-34a formed smaller tumors when growing as xenografts in immunodeficient mice compared with wild-type U251 GBM cells. 22580610 2013
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Integrative in silico analyses, a functional genetic screen, and experimental validation identified miR-34a as a tumor suppressor in proneural subtype glioblastoma. 22750848 2012
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE Collectively, our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1. 21743299 2011
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE Also, transient expression of miR-34a in glioblastoma cells strongly inhibited in vivo glioma xenograft growth. 19773441 2009