Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.550 Biomarker disease BEFREE A recent study showed that a combination of Y15 (a FAK autophosphorylation inhibitor) with temozolomide (TMZ) treatment was effective in glioblastoma (GBM) therapy. 31360198 2019
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.550 PosttranslationalModification disease BEFREE Moreover, the dimeric bicyclic ligand induced cell detachment and inhibited FAK phosphorylation in U-373 MG glioblastoma cells. 31556442 2019
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.550 AlteredExpression disease BEFREE In this report, we found that naringin can specifically inhibit the kinase activity of FAK and suppress the FAK<sup>p-Try397</sup>and its downstream pathway in glioblastoma cells. 27125297 2017
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.550 Biomarker disease BEFREE Also, knockdown- or pharmacological agent-based attenuation of EGFR, FAK or Graf (ARHGAP26)/small GTPase-mediated pathways markedly mitigated the aggressiveness of glioblastoma cells. 26377974 2015
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.550 Biomarker disease BEFREE Thus, microarray gene expression analysis can be effective in establishing genes affected in response to FAK inhibitor alone and in response to combination of Y15 with temozolomide that is important for glioblastoma therapy. 23387973 2014
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.550 Biomarker disease CTD_human Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. 12811834 2003
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.550 GeneticVariation disease UNIPROT