| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | The urinary CD80 level was significantly higher in the MCD group (3.5 ± 2.1 ng/mg creatinine) than in the focal segmental glomerulosclerosis group (1.2 ± 0.5 ng/mg creatinine, P < .001), the other glomerulopathies group (1.4 ± 0.7 ng/mg creatinine, P < .001), and the control group (0.7 ± 0.2 ng/mg creatinine, P < .001), while it showed no significant difference among the non-MCD groups. | 29507273 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Since MCD is associated with CD80 expression in glomeruli and elevated urinary excretion, we evaluated a potential role for CD80 in xenograft nephropathy. | 29722117 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our results suggest that urinary CD80 is unreliable as a differential diagnostic marker between MCD in relapse and FSGS or inherited kidney diseases. | 30470792 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Some studies suggest that subjects with steroid-sensitive MCD may express CD80 in their podocytes during relapse and that this expression is associated with high urinary levels of CD80. | 29492674 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | CD80 expression in glomeruli was a sensitive marker to diagnose MCD. | 30083478 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | CD80 levels were also significantly higher in patients with MCD than in those with FSGS (p = 0.002). | 28210837 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Sera collected from patients with MCD in relapse, but not in remission, significantly increased CD80 expression (mean ± standard deviation: 1.8 ± 0.7 vs. 0.8 ± 0.2; p < 0.004) and CD80 protein secretion by podocytes (p < 0.05 between relapse and normal controls). | 23689904 | 2013 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We have reported that children with biopsy-proven minimal change disease (MCD) express CD80 (also known as B7.1) in their podocytes and excrete high levels of CD80 in their urine during active nephrotic syndrome. | 23262434 | 2013 |