Similarly, the oxidized low-density lipoprotein receptor 1 (<i>OLR1</i>) gene, which plays an important role in the humoral immunity of the skin, and the plexin D1 (<i>PLXND1</i>) gene, which is highly expressed in tumor vasculature, were both found to be common targets of miR-27b, miR-1914, and miR-612.
Plexin D1 is abundantly expressed on both activated established tumor vasculature and malignant cells in the majority of primary and metastatic clinical tumors, as well as on macrophages and fibroblasts.