| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | phenotype | BEFREE | Using a semiquantitative score with four intensity levels, CD13 was expressed by tumor vasculature, or tumor cells, or both (composite value, intensity scores 1-3) in 93.9% of the STS. | 30125801 | 2018 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | These nanomaterials with non-toxic concentrations could cross the BBB and target CD13-overexpressing glioma and tumor vasculature in vitro and in vivo, contributing to fluorescence imaging of this brain malignancy. | 27682740 | 2017 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | The fusion protein tTF-NGR consists of the extracellular domain of the thrombogenic human tissue factor (truncated tissue factor, tTF) and the peptide GNGRAHA (NGR), a ligand of the surface protein CD13 (aminopeptidase N), upregulated on endothelial cells of tumor vessels. tTF-NGR preferentially activates blood coagulation within tumor vasculature, resulting in tumor vessel infarction and subsequent tumor growth retardation/regression. | 24136410 | 2014 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Evidence suggests that the CNGRC motif is an APN ligand which targets tumor vasculature. | 22590653 | 2012 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | Overall, WM15 was the most specific antibody for angiogenic tumor vessels, suggesting that it may be a good tool for detecting the CD13 form associated with the tumor vasculature. | 21339174 | 2011 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | Angiogenic growth factors induce the transcription of the cell surface peptidase CD13/APN in activated endothelial cells of the tumor vasculature. | 17897790 | 2007 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | It has been reported that peptides that contain asparagine-glycine-arginine (NGR) sequence home to APN in tumor vasculature. | 15952188 | 2005 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | To investigate the mechanisms of CD13/APN induction in tumor vasculature, the regulation of CD13/APN by factors contributing to angiogenic progression was studied. | 11157481 | 2001 |