Gene: DLL4 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54567
Gene Symbol: DLL4
DLL4 		0.050 Biomarker phenotype BEFREE Delta-like ligand 4-Notch (DLL4-Notch) signaling contributes to the maintenance of chemotherapy-resistant cancer stem cells and tumor vasculature. 29188408 2018
Entrez Id: 54567
Gene Symbol: DLL4
DLL4 		0.050 GeneticVariation phenotype BEFREE This prompted us to investigate the breakpoint region of the translocation, which uncovered a gene that encodes a Notch ligand, DLL4, (locus at 15q15.1), a key target in tumor vasculature. 27542210 2016
Entrez Id: 54567
Gene Symbol: DLL4
DLL4 		0.050 AlteredExpression phenotype BEFREE Under hypoxic conditions, VEGF increased Dll4 expression in the tumor vasculature. 21795478 2011
Entrez Id: 54567
Gene Symbol: DLL4
DLL4 		0.050 Biomarker phenotype BEFREE Treatment (intraperitoneally) with HMD4-2 suppressed the in vivo tumor growth with marked decrease of tumor vasculature and had no direct inhibitory effect on PK-1 cells in vitro. 20182391 2010
Entrez Id: 54567
Gene Symbol: DLL4
DLL4 		0.050 AlteredExpression phenotype BEFREE We have previously shown that the Notch ligand Delta-like 4 (DLL4) is up-regulated in tumor vasculature. 18056450 2007