Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE Incorporation of ABL-targeted oral tyrosine kinase inhibitors (TKIs) into frontline therapeutic regimens has improved outcomes for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL). 30831480 2019
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 GeneticVariation disease BEFREE This specific combination of Nutlin-3 and Tanshinone IIA is also effective in preventing the recurrence of refractory leukemia, such as Ph+ ALL with the ABL kinase T315I mutation and AML with the FLT3-ITD mutation. 30389549 2019
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE The introduction of tyrosine kinase inhibitors (TKIs) targeting the ABL kinase (such as imatinib) has dramatically improved survival of CML and Ph+ ALL patients. 31349760 2019
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE Dasatinib is a second generation ABL kinase inhibitor used in the management of chronic myeloid leukemia or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL). 29284366 2018
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia. 27582059 2016
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 GeneticVariation disease BEFREE We retrospectively analyzed adults who underwent allogeneic HSCT for CML and Ph + ALL at our institution between 2000 and 2010, and we identified subjects who had detectable BCR-ABL transcripts by polymerase chain reaction (PCR), as well as available RNA for Sanger sequencing of the ABL kinase domain, in both the pre- and post-HSCT settings. 25300870 2015
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE Dasatinib is a small-molecule inhibitor of the tyrosine kinases SRC and ABL that has been approved for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia. 25842192 2015
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 GeneticVariation disease BEFREE One patient with lymphoid BC/Ph+ ALL who harbored a T315I ABL mutation and was treated with ponatinib was found to have developed a newly acquired V216M TP53 mutation (12% of transcripts) when becoming resistant to ponatinib. 25894969 2015
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE Despite the clinical efficacy achieved with frontline therapies for BCR-ABL-positive disease, such as imatinib and second-generation ABL inhibitors like nilotinib or dasatinib that were originally designed to override insensitivity to imatinib, drug resistance still remains a challenge, especially for patients with advanced-stage chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. 25331939 2014
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 GeneticVariation disease BEFREE ABL kinase mutation and relapse in 4 pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia cases. 24652384 2014
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 GeneticVariation disease BEFREE ABL KD mutations, especially at codons 315 and 253, emerged at the time of disease recurrence in the vast majority of patients who had Ph-positive ALL and received maintenance KI therapy. 18615627 2008
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 GeneticVariation disease BEFREE A dual inhibitor of PI3K and mTOR, PI-103, was more effective than rapamycin at suppressing proliferation of mouse pre-B-ALL and human CD19+CD34+)Ph+ ALL leukemia cells treated with the ABL kinase inhibitor imatinib. 18704194 2008
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 GeneticVariation disease BEFREE The discovery of targeted ABL tyrosine kinase inhibitors has allowed significant advances in the treatment of de novo Philadelphia chromosome (Ph)-positive ALL. 20425368 2007
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE Imatinib, the ABL kinase inhibitor, is used not only for Philadelphia chromosome-positive (Ph + ) chronic myelogenous leukemia, but also for Ph + acute lymphoblastic leukemia (ALL), although resistance to the drug tends to develop in an early stage of the clinical course. 15621812 2005
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE Chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia are associated with p210BCR/ABL and p185BCR/ABL, respectively. 9050373 1997
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE We studied the tyrosine phosphorylated proteins which might be involved in the signaling pathway p185BCR-ABL using a Ph-positive acute lymphoblastic leukemia cell line. p185BCR-ABL but not p145c-abl was constitutively phosphorylated on tyrosine in this cell line. p21ras GTPase-activating protein (GAP) was physically associated with p185BCR-ABL, but not with p145c-abl, and GAP-associated proteins p62/p190 were found to be tyrosine-phosphorylated. 8289476 1994
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE Our study suggests that the origin of both p190BCR-ABL- and p210BCR-ABL-positive ALL is heterogenous with involvement of either a pluripotent precursor or a lymphoid lineage-committed hematopoietic progenitor. 8324740 1993
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 AlteredExpression disease BEFREE Expression of the ABL-BCR fusion gene in Philadelphia-positive acute lymphoblastic leukemia. 8490164 1993
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE In most cases of CML and some cases of Ph+ ALL the protooncogene ABL from 9q34 is translocated to the breakpoint cluster region (bcr) of the BCR gene at 22q11 to form a chimeric gene encoding a novel 210-kd protein (P210 BCR-ABL) with enhanced tyrosine kinase activity. 3179449 1988
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 Biomarker disease BEFREE Heterogeneity of genomic fusion of BCR and ABL in Philadelphia chromosome-positive acute lymphoblastic leukemia. 2833755 1988
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.100 AlteredExpression disease BEFREE A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia. 3027581 1987