| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | The mean IL-13 serum cytokine levels were found to be significantly high in atopic (38.48 ± 36.54) and non-atopic (36.05 ± 34.54) asthma patients whereas total serum IgE levels were significantly high at p < 0.0001 in atopic and low in non-atopic asthma patients at p < 0.003 compared to HC. | 28083766 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Moreover, maternal stress can alter fetal cytokine balance, favoring TH2 (allergic) immune responses characteristic of atopic asthma: interleukin 6 (IL-6), which has been associated with premature labor, can promote TH2 responses by stimulating production of IL-4 and IL-13. | 26676148 | 2015 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | IL-13 gene polymorphisms and their association with atopic asthma and rhinitis in Pakistani patients. | 23996716 | 2013 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility, yet serum IL-13 can be used as a marker in atopic diseases and to differentiate between atopic and non-atopic asthma. | 21425907 | 2011 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Virus-induced wheezing has frequently been associated with IL-8 polymorphisms, whereas atopic asthma and atopy have frequently been associated with Th2 cytokine gene (CD14 and IL-13) polymorphisms on chromosome 5. | 20126925 | 2009 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | The gene-gene interaction between risk alleles of each IL-13 promoter polymorphism and IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma (P=0.002, 0.010). | 17006604 | 2006 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Haplotypes of the 5' region of the IL-4 gene and SNPs in the intergene sequence between the IL-4 and IL-13 genes are associated with atopic asthma. | 11704288 | 2001 |