Reduction of nuclear HDAC2 in both CD36<sup>-/-</sup> mice liver and cultured hepatocytes was due to reduction of intracellular reactive oxygen species (ROS) level, while supplement of low-concentration hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) overcame the suppression of HDAC2 caused by CD36 deficiency, decreasing MCP-1 gene transcription and microphage migration.