| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.940 | Biomarker | disease | BEFREE | FADD deficiency sensitized more efficiently for TNFR1-mediated necroptosis than caspase-8 deficiency pointing to a caspase-8 independent inhibitory activity of FADD on TNF-induced necroptosis. | 30741924 | 2019 | ||||
|
0.940 | Biomarker | disease | BEFREE | Mixed bone marrow chimeric mice demonstrate that caspase-8 deficiency does not confer preferential expansion of synovial macrophage and dendritic cell populations, nor do caspase-8-deficient synovial populations succumb to RIPK3-mediated necroptotic death. | 28978351 | 2017 | ||||
|
0.940 | GermlineCausalMutation | disease | ORPHANET | Advances in autoimmune lymphoproliferative syndromes. | 21447005 | 2011 | ||||
|
0.940 | AlteredExpression | disease | BEFREE | Studies of patients with autoimmune lymphoproliferative syndrome (ALPS) or caspase-8 deficiency state (CEDS) demonstrated the ability of gene expression microarray analyses and small interfering RNAs (siRNA) to establish the physiologically important roles of NRAS, caspase-10, and caspase-8 for normal lymphocyte apoptosis and activation. | 18818883 | 2009 | ||||
|
0.940 | GermlineCausalMutation | disease | ORPHANET | Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome. | 16446975 | 2006 | ||||
|
0.940 | GeneticVariation | disease | UNIPROT | Thus, caspase-8 deficiency in humans is compatible with normal development and shows that caspase-8 has a postnatal role in immune activation of naive lymphocytes. | 12353035 | 2002 | ||||
|
0.940 | Biomarker | disease | BEFREE | Thus, caspase-8 deficiency in humans is compatible with normal development and shows that caspase-8 has a postnatal role in immune activation of naive lymphocytes. | 12353035 | 2002 | ||||
|
0.940 | Biomarker | disease | MGD | |||||||
|
0.940 | CausalMutation | disease | CLINVAR | |||||||
|
0.940 | Biomarker | disease | CTD_human |