Source: ALL
| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | While the production levels of TNF-α and IFN-γ were found higher by patients with vitiligo, IL-4 production was lower in patients compared with controls. | 31046170 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | After treatment, IL-2 and IFN-γ levels in vitiligo patients were lower than before treatment, but the difference was not statistically significant (p > .05), while IL-4, IL-10, IL-17, and IL-23 levels were significantly lower compared with before treatment (p < .05). | 31172649 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Also compatible with pathophysiologic concepts of vitiligo, peripheral blood mononuclear cells of one patient showed high proportions of CD8<sup>+</sup> T cells with an activated (human leukocyte antigen-DR<sup>+</sup>), memory (CD45RO<sup>+</sup>), and type 1 cytokine (interferon-γ + tumor necrosis factor-α) phenotype at vitiligo onset compared to a control cohort of alemtuzumab-treated patients with RRMS (n = 30). | 30404783 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | IFN-γ is known to be a melanocyte inhibitor of paracrine origin; it is clearly involved in the early onset of symptoms of vitiligo disease. | 29199612 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | In conclusion, IFN-γ is a promising immunological marker in vitiligo pathogenesis. | 28273427 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | The identification of IFNγ-driven immune signaling pathways has enabled discoveries of potential new treatments for vitiligo and alopecia areata, and supports initiation of larger clinical trials. | 27191524 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | Interferon-gamma Inhibits Melanogenesis and Induces Apoptosis in Melanocytes: A Pivotal Role of CD8+ Cytotoxic T Lymphocytes in Vitiligo. | 25721262 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Association of interferon-gamma and tumor necrosis factor alpha polymorphisms with susceptibility to vitiligo in Iranian patients. | 18820938 | 2009 |