Gene: PARK7 ×
Source: CURATED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 Biomarker disease CTD_human BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage. 28348719 2017
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. 23792957 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes. 23847046 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT Human DJ-1 and its homologs are novel glyoxalases. 22523093 2012
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. 19229105 2009
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. 17846173 2007
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. 14607841 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations. 15254937 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT Analyzing the PARK7/DJ1 gene in 104 EOPD patients, we identified a third mutation, c.192G>C (p.E64D), associated with EOPD in a patient of Turkish ancestry and characterized the functional significance of this amino acid substitution. 15365989 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT The role of pathogenic DJ-1 mutations in Parkinson's disease. 12953260 2003
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 Biomarker disease GENOMICS_ENGLAND Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. 12446870 2003
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. 12851414 2003
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization. 14713311 2003
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 GeneticVariation disease UNIPROT Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. 12446870 2003
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.970 Biomarker disease GENOMICS_ENGLAND