×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
Biomarker
disease
MGD
Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling.
27466203
2016
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
Biomarker
disease
GENOMICS_ENGLAND
Holoprosencephaly: ZIC2 mutation in a case with panhypopituitarism.
24706429
2014
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
Biomarker
disease
GENOMICS_ENGLAND
A broad range of ophthalmologic anomalies is part of the holoprosencephaly spectrum.
21976454
2011
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
GeneticVariation
disease
CLINVAR
Mutations in ZIC2 in human holoprosencephaly: description of a novel ZIC2 specific phenotype and comprehensive analysis of 157 individuals.
19955556
2010
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
CausalMutation
disease
CLINVAR
Mutations in ZIC2 in human holoprosencephaly: description of a novel ZIC2 specific phenotype and comprehensive analysis of 157 individuals.
19955556
2010
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
Biomarker
disease
GENOMICS_ENGLAND
Mutations in ZIC2 in human holoprosencephaly: description of a novel ZIC2 specific phenotype and comprehensive analysis of 157 individuals.
19955556
2010
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
GeneticVariation
disease
CLINVAR
The full spectrum of holoprosencephaly-associated mutations within the ZIC2 gene in humans predicts loss-of-function as the predominant disease mechanism.
19177455
2009
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
GeneticVariation
disease
UNIPROT
The full spectrum of holoprosencephaly-associated mutations within the ZIC2 gene in humans predicts loss-of-function as the predominant disease mechanism.
19177455
2009
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
Biomarker
disease
MGD
Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation.
18617531
2008
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
CausalMutation
disease
CLINVAR
In vitro analysis of partial loss-of-function ZIC2 mutations in holoprosencephaly: alanine tract expansion modulates DNA binding and transactivation.
15590697
2005
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
GeneticVariation
disease
UNIPROT
In vitro analysis of partial loss-of-function ZIC2 mutations in holoprosencephaly: alanine tract expansion modulates DNA binding and transactivation.
15590697
2005
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
GeneticVariation
disease
UNIPROT
Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: Mutation review and genotype-phenotype correlations.
15221788
2004
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
Biomarker
disease
MGD
Zic2 is required for neural crest formation and hindbrain patterning during mouse development.
14651926
2003
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
CausalMutation
disease
CLINVAR
Holoprosencephaly due to mutations in ZIC2: alanine tract expansion mutations may be caused by parental somatic recombination.
11285244
2001
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
GeneticVariation
disease
UNIPROT
Holoprosencephaly due to mutations in ZIC2: alanine tract expansion mutations may be caused by parental somatic recombination.
11285244
2001
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
Biomarker
disease
MGD
Zic2 regulates the kinetics of neurulation.
10677508
2000
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
CausalMutation
disease
CLINVAR
Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired.
9771712
1998
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
Biomarker
disease
GENOMICS_ENGLAND
Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired.
9771712
1998
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
GeneticVariation
disease
UNIPROT
Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired.
9771712
1998
×
Entrez Id:
7546
Gene Symbol:
ZIC2
ZIC2
0.900
Biomarker
disease
CTD_human