Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE Abnormal p53 expression in the epithelium of primary and recurrent pterygium specimens suggests that pterygium is a growth disorder rather than a degeneration. 9063255 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE We conclude that defective p53 tumor suppressor gene function seems to have no role in the pathogenesis of pterygium. 9793769 1998
Entrez Id: 6487
Gene Symbol: ST3GAL3
ST3GAL3
0.010 AlteredExpression disease BEFREE ST3Gal III expression was significantly lower in pterygium (0.20+/-0.02 AU [arbitrary units]) than in normal conjunctiva (0.95+/-0.12 AU). 10393028 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Fluorescence telomeric repeat amplification protocol was used to measure telomerase activity in whole pterygium samples from 9 cases and in the epithelium and stroma of pterygium from another 10 cases. p53 protein content was measured by enzyme-linked immunosorbent assay (ELISA) in tissues obtained from 7 eyes, as well as in epithelial cell suspensions collected by brush cytology in 8 eyes. 10798651 2000
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
0.020 Biomarker disease BEFREE Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines. 10892857 2000
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.030 AlteredExpression disease BEFREE Overexpression of MMP-1 and MMP-3, a phenotype previously linked with UV exposure in dermal fibroblasts to explain the pathologic finding of elastotic degeneration, suggests that pterygium head fibroblasts might be intrinsically altered by UV, which might be responsible for corneal invasion. 11146729 2001
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.020 AlteredExpression disease BEFREE Overexpression of MMP-1 and MMP-3, a phenotype previously linked with UV exposure in dermal fibroblasts to explain the pathologic finding of elastotic degeneration, suggests that pterygium head fibroblasts might be intrinsically altered by UV, which might be responsible for corneal invasion. 11146729 2001
Entrez Id: 5111
Gene Symbol: PCNA
PCNA
0.010 Biomarker disease BEFREE Immunohistochemical study of p53, p21 and PCNA in pterygium. 11368097 2001
Entrez Id: 3664
Gene Symbol: IRF6
IRF6
0.080 GeneticVariation disease BEFREE Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. 12219090 2002
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.020 Biomarker disease BEFREE IL-6 and -8 proteins were abundantly expressed, predominantly by the pterygium epithelium, with additional IL-8 immunoreactivity associated with the vascular endothelium. 12407153 2002
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.010 AlteredExpression disease BEFREE Expression of both IL-6 and -8 mRNA and protein was induced in UVB-irradiated pterygium epithelial cells in a time- and dose-dependent manner. 12407153 2002
Entrez Id: 1839
Gene Symbol: HBEGF
HBEGF
0.010 Biomarker disease BEFREE Immunohistochemistry was used to evaluate the distribution of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in pterygium tissue. 12547714 2003
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.010 Biomarker disease BEFREE HB-EGF is a potent mitogen, localized in pterygium tissue, and significantly induced by UVB in pterygium-derived epithelial cells. 12547714 2003
Entrez Id: 3485
Gene Symbol: IGFBP2
IGFBP2
0.010 AlteredExpression disease BEFREE The increased expression of IGFBP-2 mRNA and protein in pterygium fibroblasts is further strong evidence to support the transformed phenotype of these cells and helps explain why there is increased growth of fibrovascular tissue. 12556385 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker disease BEFREE We report on the presence of CTGF in pterygium and its simultaneous presence with vascular endothelial growth factor (VEGF). 12605268 2003
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.010 Biomarker disease BEFREE We report on the presence of CTGF in pterygium and its simultaneous presence with vascular endothelial growth factor (VEGF). 12605268 2003
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.030 Biomarker disease BEFREE A dose- and time-dependent increase in MMP-1 was observed when pterygium epithelial cells were exposed to UVB with no significant modulation of inhibitor activity. 14578390 2003
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.030 GeneticVariation disease BEFREE In this study, we investigated the association of the hOGG1 Ser326Cys polymorphism with pterygium in a Chinese population. 14716324 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE We have analyzed the status and expression of the p53 gene in epithelial cells derived from pterygium and have demonstrated that the p53 gene has undergone a monoallelic deletion. 15019163 2004
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.030 Biomarker disease BEFREE The correlation between pterygium and TNF-alpha-308 promoter, IL-1beta-511 promoter, IL-1beta exon 5, and IL-1 Ra polymorphisms does not exist and those polymorphisms are not useful genetic markers for pterygium susceptibility. 15184943 2005
Entrez Id: 3554
Gene Symbol: IL1R1
IL1R1
0.010 GeneticVariation disease BEFREE The correlation between pterygium and TNF-alpha-308 promoter, IL-1beta-511 promoter, IL-1beta exon 5, and IL-1 Ra polymorphisms does not exist and those polymorphisms are not useful genetic markers for pterygium susceptibility. 15184943 2005
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
0.010 GeneticVariation disease BEFREE The correlation between pterygium and TNF-alpha-308 promoter, IL-1beta-511 promoter, IL-1beta exon 5, and IL-1 Ra polymorphisms does not exist and those polymorphisms are not useful genetic markers for pterygium susceptibility. 15184943 2005
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.040 GeneticVariation disease BEFREE These results indicate GSTM1 null genotype is associated with early onset pterygium, but not associated with late onset pterygium. 15273656 2004
Entrez Id: 2946
Gene Symbol: GSTM2
GSTM2
0.010 GeneticVariation disease BEFREE Null type of glutathione S-transferase M1 polymorphism is associated with early onset pterygium. 15273656 2004
Entrez Id: 3664
Gene Symbol: IRF6
IRF6
0.080 Biomarker disease BEFREE Three of them--namely T-box transcription factor-22 (TBX22), poliovirus receptor like-1 (PVRL1), and interferon regulatory factor-6 (IRF6)--are responsible for causing X-linked cleft palate, cleft lip/palate-ectodermal dysplasia syndrome, and Van der Woude's and popliteal pterygium syndromes, respectively; they are also implied in non-syndromic cleft lip and palate. 15479962 2004