Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.010 Biomarker disease BEFREE SDF-1/CXCR4 signaling may play a vital role in pterygium and shorter axial length. 31714404 2020
Entrez Id: 3384
Gene Symbol: ICAM2
ICAM2
0.010 AlteredExpression disease BEFREE <b>Conclusion</b>: These results demonstrate, for the first time, the expressions of ICAM-2 and ICAM-3 in the pterygium. 30657707 2019
Entrez Id: 4156
Gene Symbol: MBS1
MBS1
0.010 Biomarker disease BEFREE Concurrently used MBS item numbers 42 686 (pterygium removal) with 42 641 (conjunctival autograft) and also 42 686 with any other ophthalmic item number. 29947041 2019
Entrez Id: 6707
Gene Symbol: SPRR3
SPRR3
0.010 Biomarker disease BEFREE A gene signature consisting of 11 DEGs were found to be shared by pterygium and MGD (SPRR3, SERPINB13, NMU, KRT10, IL37, KRT6B, PI3, S100A2, MAL, AURKA, and RGCC), and bioinformatics analyses showed that these overlapped DEGs were significantly enriched in pathways related to keratinization, cell-cycle regulation, and formation of the cornified envelope. 31373692 2019
Entrez Id: 1281
Gene Symbol: COL3A1
COL3A1
0.010 Biomarker disease BEFREE MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium. 31341891 2019
Entrez Id: 1282
Gene Symbol: COL4A1
COL4A1
0.010 Biomarker disease BEFREE MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium. 31341891 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.010 Biomarker disease BEFREE The microRNA-218-5p-EGFR-PI3K/Akt/mTOR axis should be further investigated for the potential treatment of pterygium. 30243568 2019
Entrez Id: 1116
Gene Symbol: CHI3L1
CHI3L1
0.010 Biomarker disease BEFREE We believe YKL-40 may play a significant role in pterygium pathogenesis. 29922975 2019
Entrez Id: 23164
Gene Symbol: MPRIP
MPRIP
0.010 AlteredExpression disease BEFREE RhoA activity was significantly upregulated in pterygium fibroblast cells (PFCs) and UV-NCFCs, and myosin phosphatase-Rho interacting protein (MRIP) was upregulated, and myosin phosphatase target subunit 1 (MYPT1) was downregulated in PFCs. 31547113 2019
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.010 Biomarker disease BEFREE The microRNA-218-5p-EGFR-PI3K/Akt/mTOR axis should be further investigated for the potential treatment of pterygium. 30243568 2019
Entrez Id: 7291
Gene Symbol: TWIST1
TWIST1
0.010 AlteredExpression disease BEFREE Using real-time polymerase chain reaction, the twist-related protein 1 (TWIST1) expression was compared in primary pterygium and normal conjunctiva. 30847945 2019
Entrez Id: 407024
Gene Symbol: MIR29B1
MIR29B1
0.010 Biomarker disease BEFREE MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium. 31341891 2019
Entrez Id: 100422995
Gene Symbol: MIR3175
MIR3175
0.010 Biomarker disease BEFREE In conclusion, our data suggested that the MiR-3175-Smad7 axis may play a critical role in pathogenesis and development of pterygium. 31774554 2019
Entrez Id: 8482
Gene Symbol: SEMA7A
SEMA7A
0.010 AlteredExpression disease BEFREE Semaphorin 7a was highly expressed in the primary pterygium and recurrent pterygium samples than that of the normal conjunctival tissue. 31236342 2019
Entrez Id: 51232
Gene Symbol: CRIM1
CRIM1
0.010 Biomarker disease BEFREE We propose here a series of intracellular events where CRIM1 regulation of the ERK pathway prevents UV-induced cell proliferation and may play an important role in the in the pathogenesis of pterygium. 30365943 2019
Entrez Id: 10630
Gene Symbol: PDPN
PDPN
0.010 AlteredExpression disease BEFREE Primary grade 2 pterygium (n=20) and normal conjunctiva (n=20) biopsies were obtained during surgery after written informed consent. mRNA expression for CD31, podoplanin, and VEGF (isoforms VEGF-A and VEGF-165) were determined by qRT-PCR. 30821336 2019
Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
0.010 Biomarker disease BEFREE In conclusion, our data suggested that the MiR-3175-Smad7 axis may play a critical role in pathogenesis and development of pterygium. 31774554 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.010 Biomarker disease BEFREE The microRNA-218-5p-EGFR-PI3K/Akt/mTOR axis should be further investigated for the potential treatment of pterygium. 30243568 2019
Entrez Id: 407025
Gene Symbol: MIR29B2
MIR29B2
0.010 Biomarker disease BEFREE MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium. 31341891 2019
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
0.010 Biomarker disease BEFREE We propose here a series of intracellular events where CRIM1 regulation of the ERK pathway prevents UV-induced cell proliferation and may play an important role in the in the pathogenesis of pterygium. 30365943 2019
Entrez Id: 3385
Gene Symbol: ICAM3
ICAM3
0.010 Biomarker disease BEFREE <b>Conclusion</b>: These results demonstrate, for the first time, the expressions of ICAM-2 and ICAM-3 in the pterygium. 30657707 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.010 Biomarker disease BEFREE The microRNA-218-5p-EGFR-PI3K/Akt/mTOR axis should be further investigated for the potential treatment of pterygium. 30243568 2019
Entrez Id: 8720
Gene Symbol: MBTPS1
MBTPS1
0.010 AlteredExpression disease BEFREE We found that the activation of the S1P receptor-Rho cascade was observed in pterygium tissue. 31547113 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.010 AlteredExpression disease BEFREE The expression of PSMB5 and Nrf2 by pterygium fibroblasts was suppressed in a dose dependent manner following UVB radiation of 0-50 mJ/cm<sup>2</sup> doses. 30563490 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.010 AlteredExpression disease BEFREE As the severity of the pterygium increased, the miR-21 levels increased (p=0.004, rs=0.373, Spearman's rank correlation coefficient). 30967746 2018