Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3384
Gene Symbol: ICAM2
ICAM2
0.010 AlteredExpression disease BEFREE <b>Conclusion</b>: These results demonstrate, for the first time, the expressions of ICAM-2 and ICAM-3 in the pterygium. 30657707 2019
Entrez Id: 3385
Gene Symbol: ICAM3
ICAM3
0.010 Biomarker disease BEFREE <b>Conclusion</b>: These results demonstrate, for the first time, the expressions of ICAM-2 and ICAM-3 in the pterygium. 30657707 2019
Entrez Id: 3872
Gene Symbol: KRT17
KRT17
0.010 AlteredExpression disease BEFREE Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medium to examine the expression of IPO13 and K17. 23559854 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.020 Biomarker disease BEFREE Pterygium cell line (PECs) cell models were used to confirm the effect of β-catenin, miR-221, and p27Kip1 gene in the proliferation of pterygium cells. 25053875 2014
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
0.010 Biomarker disease BEFREE Pterygium cell line (PECs) cell models were used to confirm the effect of β-catenin, miR-221, and p27Kip1 gene in the proliferation of pterygium cells. 25053875 2014
Entrez Id: 5366
Gene Symbol: PMAIP1
PMAIP1
0.010 GeneticVariation disease BEFREE Pterygium clinical samples were cultured under airlifting conditions with or without APR-246 for 4 days. p63, K10, β-catenin, and TCF-4 expression in pterygial epithelium was determined by immunofluorescent staining and real-time PCR. 26868746 2016
Entrez Id: 4035
Gene Symbol: LRP1
LRP1
0.010 GeneticVariation disease BEFREE Pterygium clinical samples were cultured under airlifting conditions with or without APR-246 for 4 days. p63, K10, β-catenin, and TCF-4 expression in pterygial epithelium was determined by immunofluorescent staining and real-time PCR. 26868746 2016
Entrez Id: 6487
Gene Symbol: ST3GAL3
ST3GAL3
0.010 AlteredExpression disease BEFREE ST3Gal III expression was significantly lower in pterygium (0.20+/-0.02 AU [arbitrary units]) than in normal conjunctiva (0.95+/-0.12 AU). 10393028 1999
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.020 AlteredExpression disease BEFREE beta-Catenin and E-cadherin expression were examined in surgically excised tissue and eye bank corneas with intact pterygium. 17389479 2007
Entrez Id: 5337
Gene Symbol: PLD1
PLD1
0.010 AlteredExpression disease BEFREE PLD1, 2, 3, and 4 transcripts were detected in normal conjunctiva tissue, and types 2, 3, and 4 were upregulated in pterygium. 18580262 2008
Entrez Id: 6279
Gene Symbol: S100A8
S100A8
0.020 AlteredExpression disease BEFREE S100A8 and S100A9 were localized in the superficial layer of both pterygium and normal conjunctiva epithelium, with higher levels in pterygium than uninvolved conjunctiva. 19223989 2009
Entrez Id: 6277
Gene Symbol: S100A6
S100A6
0.010 AlteredExpression disease BEFREE S100A6 expression was strong in the superficial layer of pterygium epithelium but relatively weaker in the suprabasal and superficial cells of normal conjunctiva epithelium. 19223989 2009
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.010 AlteredExpression disease BEFREE MMP-2 and MMP-9 expression by pterygium fibroblasts is significantly increased after the progression of pterygium. 19420332 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker disease BEFREE VEGFA expression may have potential for use in the selective treatment of pterygium with anti-VEGFA agents. 20198298 2010
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
0.020 GeneticVariation disease BEFREE XRCC1 (Arg399 Glu) is correlated with pterygium and might become a potential marker for the prediction of pterygium susceptibility. 20577654 2010
Entrez Id: 1146
Gene Symbol: CHRNG
CHRNG
0.010 GeneticVariation disease BEFREE CHRNG genotype-phenotype correlations in the multiple pterygium syndromes. 22167768 2012
Entrez Id: 6678
Gene Symbol: SPARC
SPARC
0.010 AlteredExpression disease BEFREE SPARC was upregulated in pterygium and may collaborate with increased MMP-3 in some patients to account for many of the phenotypic properties characteristic of pterygium. 22222271 2012
Entrez Id: 6901
Gene Symbol: TAZ
TAZ
0.010 AlteredExpression disease BEFREE TAZ expression was upregulated in mitotic conjunctiva epithelial cells, proliferating conjunctiva epithelial cells, TGFβ treated conjunctiva epithelial cells and human pterygium epithelium. 22690118 2012
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.030 AlteredExpression disease BEFREE CYP1A1 protein expression was significantly greater in the pterygium group than in the control group (p<0.0001). 22876118 2012
Entrez Id: 9670
Gene Symbol: IPO13
IPO13
0.010 AlteredExpression disease BEFREE IPO13 activity was significantly increased in the basal layer of the epithelium of the pterygium. 23559854 2013
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.010 AlteredExpression disease BEFREE Telomerase reverse transcriptase was expressed, and p53 and p16 levels were reduced in immortalized pterygium fibroblast cells. 24012806 2013
Entrez Id: 6279
Gene Symbol: S100A8
S100A8
0.020 Biomarker disease BEFREE S100A8/9 may be an upstream trigger for inflammation and other disease pathways in pterygium. 24825356 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.030 AlteredExpression disease BEFREE TNF-α upregulates HIF-1α expression in pterygium fibroblasts and enhances their susceptibility to VEGF independent of hypoxia. 28803935 2017
Entrez Id: 8482
Gene Symbol: SEMA7A
SEMA7A
0.010 AlteredExpression disease BEFREE Semaphorin 7a was highly expressed in the primary pterygium and recurrent pterygium samples than that of the normal conjunctival tissue. 31236342 2019
Entrez Id: 407024
Gene Symbol: MIR29B1
MIR29B1
0.010 Biomarker disease BEFREE MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium. 31341891 2019