Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407025
Gene Symbol: MIR29B2
MIR29B2
0.010 Biomarker disease BEFREE MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium. 31341891 2019
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.010 Biomarker disease BEFREE SDF-1/CXCR4 signaling may play a vital role in pterygium and shorter axial length. 31714404 2020
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
0.030 Biomarker disease BEFREE A dose- and time-dependent increase in MMP-1 was observed when pterygium epithelial cells were exposed to UVB with no significant modulation of inhibitor activity. 14578390 2003
Entrez Id: 6707
Gene Symbol: SPRR3
SPRR3
0.010 Biomarker disease BEFREE A gene signature consisting of 11 DEGs were found to be shared by pterygium and MGD (SPRR3, SERPINB13, NMU, KRT10, IL37, KRT6B, PI3, S100A2, MAL, AURKA, and RGCC), and bioinformatics analyses showed that these overlapped DEGs were significantly enriched in pathways related to keratinization, cell-cycle regulation, and formation of the cornified envelope. 31373692 2019
Entrez Id: 54101
Gene Symbol: RIPK4
RIPK4
0.030 Biomarker disease BEFREE A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes. 25430793 2015
Entrez Id: 3664
Gene Symbol: IRF6
IRF6
0.080 Biomarker disease BEFREE A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes. 25430793 2015
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
0.020 AlteredExpression disease BEFREE A significant correlation between the TRPV1 and TRPV3 expression levels (P<0.001) was detected independently of pterygium recurrence. 28849159 2017
Entrez Id: 162514
Gene Symbol: TRPV3
TRPV3
0.010 AlteredExpression disease BEFREE A significant correlation between the TRPV1 and TRPV3 expression levels (P<0.001) was detected independently of pterygium recurrence. 28849159 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.010 Biomarker disease BEFREE A statistically significant difference was found between the pterygium and control groups for the ACE I/D polymorphism (p<0.001). 25341451 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE Abnormal p53 expression in the epithelium of primary and recurrent pterygium specimens suggests that pterygium is a growth disorder rather than a degeneration. 9063255 1997
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.010 AlteredExpression disease BEFREE Additionally, mTOR expression was significantly correlated with α-SMA expression (ρ = 0.269, p = 0.031) in pterygium. 28623647 2017
Entrez Id: 6607
Gene Symbol: SMN2
SMN2
0.030 AlteredExpression disease BEFREE Additionally, mTOR expression was significantly correlated with α-SMA expression (ρ = 0.269, p = 0.031) in pterygium. 28623647 2017
Entrez Id: 6606
Gene Symbol: SMN1
SMN1
0.030 AlteredExpression disease BEFREE Additionally, mTOR expression was significantly correlated with α-SMA expression (ρ = 0.269, p = 0.031) in pterygium. 28623647 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE After p53 protein was found to be abnormally expressed in the epithelium, researchers suggested that a pterygium may be a tumor, but additional evidence is required to support this hypothesis. 17149367 2006
Entrez Id: 7001
Gene Symbol: PRDX2
PRDX2
0.030 Biomarker disease BEFREE Although, these results suggest that overexpression of peroxiredoxin 2 in pterygium could protect the cell against oxidative stress-induced apoptosis, further studies are required to establish the functional role of peroxiredoxin 2 in pterygium to determine its role in peroxidation and apoptosis in this pathology. 23499777 2013
Entrez Id: 218
Gene Symbol: ALDH3A1
ALDH3A1
0.010 AlteredExpression disease BEFREE Among these genes, we chose three proteins, aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1), protein disulfide-isomerase A3 (PDIA3), and peroxiredoxin-2 (PRDX2), that were significantly upregulated in pterygium and further increased in recurrent pterygium. 25221425 2014
Entrez Id: 7001
Gene Symbol: PRDX2
PRDX2
0.030 AlteredExpression disease BEFREE Among these genes, we chose three proteins, aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1), protein disulfide-isomerase A3 (PDIA3), and peroxiredoxin-2 (PRDX2), that were significantly upregulated in pterygium and further increased in recurrent pterygium. 25221425 2014
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
0.010 AlteredExpression disease BEFREE An expression of RAD50 gene in the conjunctiva originating from eyes with pterygium in comparison to the conjunctiva of control group was shown to be considerably higher. 21077755 2011
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.030 Biomarker disease BEFREE And to show the disruption of MDM2-p53 interaction could reactive the functions of p53 in pterygium. 29932882 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE And to show the disruption of MDM2-p53 interaction could reactive the functions of p53 in pterygium. 29932882 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker disease BEFREE Anti-fibrotic, anti-VEGF or radiotherapy treatments as adjuvants for pterygium excision: a systematic review and network meta-analysis. 29178848 2017
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 AlteredExpression disease BEFREE Antibodies raised against VEGF and p53 were used to analyze the distribution and expression of these markers in pterygium and normal human conjunctiva were used as negative control. 19481369 2011
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.010 AlteredExpression disease BEFREE As the severity of the pterygium increased, the miR-21 levels increased (p=0.004, rs=0.373, Spearman's rank correlation coefficient). 30967746 2018
Entrez Id: 2547
Gene Symbol: XRCC6
XRCC6
0.010 GeneticVariation disease BEFREE Because pterygium is an UV-related uncontrolled cell proliferation, it is logical to assume polymorphisms of Ku70 is associated with genetic predisposition to pterygium. 17768380 2007
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
0.020 Biomarker disease BEFREE Because the polymorphism of hOGG1 was reported to be associated with pterygium, it is logical to assume the correlation between XRCC1, XPA, and XPD polymorphisms and pterygium formation. 20431719 2010