×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.800
Biomarker
disease
CLINGEN
Smad4 acts as tumor suppressor by antagonizing lymphangiogenesis in colorectal cancer.
25680269
2015
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
0.800
GermlineCausalMutation
disease
ORPHANET
The rate of germline mutations and large deletions of SMAD4 and BMPR1A in juvenile polyposis.
18823382
2009
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.800
GermlineCausalMutation
disease
ORPHANET
The rate of germline mutations and large deletions of SMAD4 and BMPR1A in juvenile polyposis.
18823382
2009
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
0.800
Biomarker
disease
CLINGEN
Cyclooxygenase-2 expression in polyps from a patient with juvenile polyposis syndrome with mutant BMPR1A.
17325551
2007
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
0.800
Biomarker
disease
CLINGEN
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling.
15378062
2004
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.800
Biomarker
disease
CLINGEN
The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations.
15235019
2004
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.800
Biomarker
disease
CLINGEN
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
14534577
2003
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
0.800
Biomarker
disease
CLINGEN
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.
11536076
2001
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
0.800
Biomarker
disease
CLINGEN
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.
11381269
2001
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.800
Biomarker
disease
MGD
Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.
10626800
1999
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.800
Biomarker
disease
CLINGEN
A gene for familial juvenile polyposis maps to chromosome 18q21.1.
9545410
1998
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.800
Biomarker
disease
CLINGEN
Mutations in the SMAD4/DPC4 gene in juvenile polyposis.
9582123
1998
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.800
Biomarker
disease
CLINGEN
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.
9482899
1998
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.800
Biomarker
disease
CLINGEN
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.
9506519
1998
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
0.800
Biomarker
disease
MGD
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
0.800
Biomarker
disease
CTD_human
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
0.800
Biomarker
disease
CTD_human
×
Entrez Id:
2022
Gene Symbol:
ENG
ENG
0.500
Biomarker
disease
CLINGEN
Syndecan-1, Epithelial-Mesenchymal Transition Markers (E-cadherin/β-catenin) and Neoangiogenesis-related Proteins (PCAM-1 and Endoglin) in Colorectal Cancer.
27127133
2016
×
Entrez Id:
2022
Gene Symbol:
ENG
ENG
0.500
Biomarker
disease
CLINGEN
Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps.
23399955
2013
×
Entrez Id:
2022
Gene Symbol:
ENG
ENG
0.500
GeneticVariation
disease
ORPHANET
Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis.
18178612
2008
×
Entrez Id:
2022
Gene Symbol:
ENG
ENG
0.500
GeneticVariation
disease
ORPHANET
ENG mutations in MADH4/BMPR1A mutation negative patients with juvenile polyposis.
17204053
2007
×
Entrez Id:
2022
Gene Symbol:
ENG
ENG
0.500
Biomarker
disease
CLINGEN
Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis.
16287957
2005
×
Entrez Id:
324
Gene Symbol:
APC
APC
0.020
AlteredExpression
disease
BEFREE
We evaluated beta-catenin and full-length APC protein expression in JPs from children with JPs and JPC .
15557107
2005
×
Entrez Id:
324
Gene Symbol:
APC
APC
0.020
GeneticVariation
disease
BEFREE
Familial juvenile polyposis coli with APC gene mutation.
9382065
1997
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
0.010
AlteredExpression
disease
BEFREE
COX-2 expression was also significantly higher in the JPC group compared to SRPs.
27072264
2016