|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings provide an understanding of how BCR-mediated signals impact telomerase modulation in IGHV mutation-based subgroups of B-CLL and normal B cells.
|
22875913 |
2012 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In recent decades, numerous prognostic markers, such as immunoglobulin variable region heavy-chain (IgVH) mutational status, ZAP-70 and the expression of CD38 on leukaemic cells were introduced to screen for patients likely to have progressive course of B-CLL bearing the potential to facilitate risk-adapted treatment strategies.
|
19247976 |
2009 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Telomere length is associated with mutation status of the immunoglobulin heavy chain variable (IGHV) gene and clinical course in B-cell chronic lymphocytic leukemia (B-CLL).
|
18045969 |
2008 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In classic RT, 18/23 B-CLL cases (78%) showed clonal progression to DLBCL with identical IgVH sequences in both lymphoma components, whereas in 5 cases (22%) the DLBCL was clonally unrelated.
|
17895764 |
2007 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The second group included 19 cases, mostly diagnosed as B-cell chronic lymphocytic leukemia (B-CLL), and characterized by few additional chromosomal changes (e.g. trisomy 12) and unmutated IgVH genes.
|
17495977 |
2007 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Probes for 13q14 (D13S319), 17p13 (p53), the centromere of chromosome 12 (CEP12), and 14q32 (IGHC/IGHV) were applied to detect chromosomal aberrations in peripheral blood samples from 83 B-CLL patients (60 men, 23 women).
|
17562621 |
2007 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Bone marrow infiltration pattern in B-cell chronic lymphocytic leukemia is related to immunoglobulin heavy-chain variable region mutation status and expression of 70-kd zeta-associated protein (ZAP-70).
|
16938520 |
2006 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, discordant ISO(+)TNK(-) cases had a IgV(H) gene mutation profile similar to that of concordantly positive cases and different from ZAP-70 concordantly negative B-CLL.
|
16906587 |
2006 |
|
LOC102724971
|
0.100 |
Biomarker
|
disease |
BEFREE |
Zeta-chain associated protein of 70kDa (ZAP-70) is the most promising surrogate marker for the immunoglobulin heavy chain variable region (IgV(H)) mutation status in B-cell chronic lymphocytic leukemia (B-CLL).Crespo et al. proposed the detection of ZAP-70 by flow cytometry.
|
16906577 |
2006 |
|
LOC102724971
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent advances in the characterization of both B-CLL and normal B cell subpopulations by phenotypic analysis, global gene expression profiling, as well as extensive IgV gene repertoire analyses have shed new light on the phenotype and the cell derivation of B-CLL and provided novel hypotheses concerning its pathogenesis.
|
16329192 |
2005 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD1d was detected by flow cytometric analyses on leukemic cells of all B-CLL cases studied (n = 38) and was expressed at higher density on cells carrying unmutated immunoglobulin variable region (IgV) genes.
|
14961579 |
2004 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In B-cell chronic lymphocytic leukemia (B-CLL), somatic mutation of IgVH genes defines a subgroup with favorable prognosis, whereas the absence of IgVH mutations is correlated with a worse outcome.
|
14961033 |
2004 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we demonstrate that some cases of B-CLL involved in lymph node carried mutated VH genes and showed intraclonal diversity like the tumor cells in the peripheral blood.
|
11699415 |
2001 |
|
LOC102724971
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evidence for immunoglobulin heavy chain variable region gene replacement in a patient with B cell chronic lymphocytic leukemia.
|
8751479 |
1996 |