Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE These findings provide an understanding of how BCR-mediated signals impact telomerase modulation in IGHV mutation-based subgroups of B-CLL and normal B cells. 22875913 2012
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE Telomere length is associated with mutation status of the immunoglobulin heavy chain variable (IGHV) gene and clinical course in B-cell chronic lymphocytic leukemia (B-CLL). 18045969 2008
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE To address the proposition that familial B-cell chronic lymphocytic leukemia (CLL) may exhibit a more restricted phenotype than sporadic CLL with respect to immunoglobulin gene usage or ontogenic development, we compared immunoglobulin (Ig) heavy chain variable region (VH) gene usage and IgVH mutation status in 327 patients with CLL from 214 families with 724 patients with sporadic cases. 18424666 2008
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE The second group included 19 cases, mostly diagnosed as B-cell chronic lymphocytic leukemia (B-CLL), and characterized by few additional chromosomal changes (e.g. trisomy 12) and unmutated IgVH genes. 17495977 2007
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE In classic RT, 18/23 B-CLL cases (78%) showed clonal progression to DLBCL with identical IgVH sequences in both lymphoma components, whereas in 5 cases (22%) the DLBCL was clonally unrelated. 17895764 2007
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE Probes for 13q14 (D13S319), 17p13 (p53), the centromere of chromosome 12 (CEP12), and 14q32 (IGHC/IGHV) were applied to detect chromosomal aberrations in peripheral blood samples from 83 B-CLL patients (60 men, 23 women). 17562621 2007
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 Biomarker disease BEFREE Zeta-chain associated protein of 70kDa (ZAP-70) is the most promising surrogate marker for the immunoglobulin heavy chain variable region (IgV(H)) mutation status in B-cell chronic lymphocytic leukemia (B-CLL).Crespo et al. proposed the detection of ZAP-70 by flow cytometry. 16906577 2006
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE Bone marrow infiltration pattern in B-cell chronic lymphocytic leukemia is related to immunoglobulin heavy-chain variable region mutation status and expression of 70-kd zeta-associated protein (ZAP-70). 16938520 2006
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE Moreover, discordant ISO(+)TNK(-) cases had a IgV(H) gene mutation profile similar to that of concordantly positive cases and different from ZAP-70 concordantly negative B-CLL. 16906587 2006
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE In B-cell chronic lymphocytic leukemia (B-CLL), somatic mutation of IgVH genes defines a subgroup with favorable prognosis, whereas the absence of IgVH mutations is correlated with a worse outcome. 14961033 2004
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE Here we demonstrate that some cases of B-CLL involved in lymph node carried mutated VH genes and showed intraclonal diversity like the tumor cells in the peripheral blood. 11699415 2001
Entrez Id: 28402
Gene Symbol: IGHV3-69-1
IGHV3-69-1
0.100 GeneticVariation disease BEFREE Evidence for immunoglobulin heavy chain variable region gene replacement in a patient with B cell chronic lymphocytic leukemia. 8751479 1996