Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 GeneticVariation disease BEFREE For the first time, the present study was aimed to evaluate the probable effects of ABCB1 T3435C polymorphism on clinical and laboratory features of Kurdish patients with B-CLL. 25586345 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 Biomarker disease BEFREE APO866 and Pgp inhibitors show a strong synergistic cooperation in leukemia cells, including acute myelogenous leukemia (AML) and B-cell chronic lymphocytic leukemia (B-CLL) samples. 25964294 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 GeneticVariation disease BEFREE Taken together, these data indicate that the MDR1 C3435T SNP may carry an increased risk of developing B-CLL, possibly by virtue of decreased protection against P-gp-substrate carcinogens. 17085864 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 AlteredExpression disease BEFREE The relevance of multidrug resistance-associated P-glycoprotein expression in the treatment response of B-cell chronic lymphocytic leukemia. 11114132 2000
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 AlteredExpression disease BEFREE Expression of mdr1 and mrp in the normal B-cell homologue of B-cell chronic lymphocytic leukaemia. 9074409 1997
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 GeneticVariation disease BEFREE Multidrug resistance (MDR) was investigated in peripheral blood cells isolated from 40 patients with B cell chronic lymphocytic leukemia (B-CLL) and from 7 healthy volunteers, using a flow cytometric assay that detects cellular efflux of the fluorescent dye rhodamine 123 (Rh 123), which has been demonstrated to be transported from the cell by the P-glycoprotein pump. 7484017 1995
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 AlteredExpression disease BEFREE These findings suggest that P-glycoprotein overexpression in B-CLL is intrinsic rather than acquired and that P-glycoprotein activity is enhanced after exposure to multidrug resistance-associated drugs. 8105101 1993
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 GeneticVariation disease BEFREE p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. 8241511 1993
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.090 AlteredExpression disease BEFREE Expression of mdr1 was found in samples from patients with acute nonlymphocytic leukemia (13 of 17), chronic myelocytic leukemia (CML, chronic phase, 10 of 10; blast crisis, three of four), acute lymphocytic leukemia (ALL, eight of 11), B-cell chronic lymphocytic leukemia (B-CLL, 17 of 17), hairy cell leukemia (HCL, one of two), and T-cell prolymphocytic leukemia (one of one), but not in B-cell prolymphocytic leukemia (B-PLL, 0 of seven). 1972761 1990