Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
0.200 Therapeutic disease RGD Glucagon-Like Peptide-1 (GLP-1) Treatment Ameliorates Cognitive Impairment by Attenuating Arc Expression in Type 2 Diabetic Rats. 28885995 2017
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
0.200 Therapeutic disease RGD Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3β signaling pathway. 26970304 2016
Entrez Id: 177
Gene Symbol: AGER
AGER
0.200 Therapeutic disease RGD Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats. 24291733 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 Therapeutic disease RGD Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats. 24291733 2014
Entrez Id: 177
Gene Symbol: AGER
AGER
0.200 Therapeutic disease RGD Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats. 23529380 2013
Entrez Id: 4804
Gene Symbol: NGFR
NGFR
0.200 Therapeutic disease RGD Vascular and neuronal protection induced by the ocular administration of nerve growth factor in diabetic-induced rat encephalopathy. 23528019 2013
Entrez Id: 1843
Gene Symbol: DUSP1
DUSP1
0.200 Biomarker disease RGD Expression changes of growth-associated protein-43 (GAP-43) and mitogen-activated protein kinase phosphatase-1 (MKP-1) and in hippocampus of streptozotocin-induced diabetic cognitive impairment rats. 17601561 2007
Entrez Id: 3934
Gene Symbol: LCN2
LCN2
0.020 Biomarker disease BEFREE Taken together, our findings highlight the critical role of LCN2 in the pathogenesis of diabetic encephalopathy. 30761088 2019
Entrez Id: 3934
Gene Symbol: LCN2
LCN2
0.020 Biomarker disease BEFREE Corrigendum: Role of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy. 31024460 2019
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.020 Biomarker disease BEFREE Together, our data suggest that PI3k/Akt/mTOR signaling may promote the development of DE through suppression of macrophage autophagy. 30346929 2018
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.020 Biomarker disease BEFREE Together, our data suggest that PI3k/Akt/mTOR signaling may promote the development of DE through suppression of macrophage autophagy. 30346929 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.020 Biomarker disease BEFREE Together, our data suggest that PI3k/Akt/mTOR signaling may promote the development of DE through suppression of macrophage autophagy. 30346929 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.020 Biomarker disease BEFREE Taken together, this study demonstrates that Gas attenuates the diabetic encephalopathy by inhibiting ER stress and NLRP3 inflammasome activation. 30544722 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.020 Biomarker disease BEFREE Together, our data suggest that PI3k/Akt/mTOR signaling may promote the development of DE through suppression of macrophage autophagy. 30346929 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.020 Biomarker disease BEFREE Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. 30175975 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.020 Biomarker disease BEFREE Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. 30175975 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.020 Biomarker disease BEFREE The purpose of this study was to explore the role of NLRP3 inflammasome in DEP. 29495433 2018
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.020 Biomarker disease BEFREE Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. 30175975 2018
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.020 Biomarker disease BEFREE Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. 30175975 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.010 Biomarker disease BEFREE This study suggests that the activation of the Nrf2-ARE signalling pathway might be a therapeutic target for the treatment of diabetic encephalopathy. 31542051 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.010 Biomarker disease BEFREE This study was designed to investigate the effect of metformin on hyperphosphorylated tau proteins in diabetic encephalopathy (DE) by regulating autophagy clearance. db/db mice were randomly divided into four groups, db/+ mice were used as control group. 30219731 2019
Entrez Id: 1182
Gene Symbol: CLCN3
CLCN3
0.010 Biomarker disease BEFREE The CLC-3 might be modulated by TGF- beta /TGF- beta RII signaling pathway during the development of DE. 30468668 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.010 AlteredExpression disease BEFREE The results demonstrated that Pino could suppress the nuclear translocation of NF-κB and decrease TNF-α expression in the cerebral cortex and the hippocampus of DE mice. 29150085 2018
Entrez Id: 2739
Gene Symbol: GLO1
GLO1
0.010 Biomarker disease BEFREE Therefore, Glo-1 and MG have been implicated in the pathogenesis of diabetic encephalopathy. 30062553 2018
Entrez Id: 494333
Gene Symbol: MIR384
MIR384
0.010 AlteredExpression disease BEFREE Thus, these data suggest that downregulation of miR-384-5p in the inflammatory macrophages may enhance macrophage autophagy and contribute to the development of diabetic encephalopathy, which may be suppressed by re-expression of miR-384-5p in macrophages. 29511445 2018