Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6. 27099147 2016
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Overexpression of Bcl2 protein predicts chemoresistance in acute myeloid leukemia: its correlation with FLT3. 23906301 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation. 22409268 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Combined effects of FLT3 and NF-κB selective inhibitors on acute myeloid leukemia in vivo. 21928377 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment. 23036488 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Synergistic effect of arsenic trioxide and flt3 inhibition on cells with flt3 internal tandem duplication. 17050201 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies. 21482694 2011
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. 21441929 2011
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		0.520 Biomarker disease CTD_human Micro-RNAs and copy number changes: new levels of gene regulation in acute myeloid leukemia. 19822134 2010
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.510 Biomarker disease CTD_human Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. 21441929 2011
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.510 Biomarker disease CTD_human Dynamics of clonal evolution in myelodysplastic syndromes. 27992414 2017
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.510 Biomarker disease CTD_human Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib. 23877794 2013
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.510 Biomarker disease CTD_human Micro-RNAs and copy number changes: new levels of gene regulation in acute myeloid leukemia. 19822134 2010
Entrez Id: 4869
Gene Symbol: NPM1
NPM1 		0.510 Biomarker disease CTD_human Subtype-specific regulatory network rewiring in acute myeloid leukemia. 30420649 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.500 Biomarker disease CTD_human
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1 		0.400 Biomarker disease CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229 2008
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1 		0.400 Biomarker disease BEFREE A diagnosis of AML with maturation (AML-M2) and AML1/ETO was made. 30921216 2019
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1 		0.400 Biomarker disease BEFREE The Section of Hematology, Department of Pathology and Laboratory Medicine at King Faisal Specialist Hospital and Research Center has shared this experience during the last 10 years with more than 6,546 samples submitted for the analysis of different gene rearrangements, fusion gene transcripts and gene mutations including Ig heavy chain gene rearrangement for B-cell malignancies, T-cell receptor gamma chain gene rearrangement for T-cell malignancies, BCR/ABL-P210 and P190 fusion gene transcripts, for chronic myeloid leukemia and Philadelphia positive acute lymphoblastic leukemia, PML/RARalpha fusion gene for promyelocytic leukemia, AML1/ETO for acute myeloid leukemia AML-M2 with t8;21, CBFB/MYH11 for AML M4E0 with inv 16, BCL-2 for follicular lymphoma, and BCL-1 for mantle cell lymphoma. 16228048 2005
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1 		0.400 Biomarker disease BEFREE Aml1/ETO and Pml/RARA rearrangements in a case of AML-M2 acute myeloblastic leukemia with t(15;17). 10221524 1999
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1 		0.400 Biomarker disease CTD_human The genomic landscape of core-binding factor acute myeloid leukemias. 27798625 2016
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1 		0.400 Biomarker disease BEFREE The chromosomal translocation t(8;21), generating the AML1-ETO fusion protein, is frequently associated with French-American-British (FAB) type M2 acute myeloid leukemia (AML). t(8;21) fuses the runt domain from the hematopoietic transcription factor RUNX1 with almost the entire transcriptional repressor ETO. 16390317 2005
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1 		0.390 Biomarker disease BEFREE A diagnosis of AML with maturation (AML-M2) and AML1/ETO was made. 30921216 2019
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1 		0.390 Biomarker disease CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229 2008
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1 		0.390 Biomarker disease CTD_human Subtype-specific regulatory network rewiring in acute myeloid leukemia. 30420649 2019
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1 		0.390 Biomarker disease CTD_human The genomic landscape of core-binding factor acute myeloid leukemias. 27798625 2016