Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE This study suggested that T2DM, Lp(a), HDL-c, and ApoA1 were risk factors of CAD and that the IL-17A rs2275913 and IL-23R rs6682925 polymorphisms may contribute to susceptibility to CAD. 31074535 2019
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 AlteredExpression disease BEFREE We found that the levels of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) and apolipoprotein A-1 antisense RNA (APOA1-AS) were significantly increased in CAD patients (KCNQ1OT1 increased by 2.38-fold, P = 0.00042; HIF1A-AS2 increased by 2.00-fold, P = 0.0001; APOA1-AS increased by 4.52-fold, P = 0.000048). 30941792 2019
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Amyloid deposits of WT apolipoprotein A-I (apoA-I), the main protein component of high-density lipoprotein, accumulate in atherosclerotic plaques where they may contribute to coronary artery disease by increasing plaque burden and instability. 29853648 2018
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE In fact, a significant increase of plasmatic triglycerides (TG) level, atherogenic lipid ratios (TC/HDL-C,TG/HDL-C, LDL-C/HDL-C); and ApoB/ApoA1 was observed in the CAD group comparatively to controls (p < 0.001). 28806974 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE A stronger association between APOA1-75G/A polymorphisms and CAD risk was present in the studies consistent with HWE. 28721149 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and the Women's Health Study. 28775061 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Anti-apoA-1 IgG are independent predictors of nonfatal incident CAD in the general population. 29074586 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE ApoA1 showed negative association and Lp-PLA<sub>2</sub> concentration showed positive association with risk for CAD. 29302464 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease CTD_human Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. 27135400 2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 AlteredExpression disease BEFREE The proinflammatory enzyme myeloperoxidase induces both oxidative modification and nitrosylation of specific residues on plasma and arterial apolipoprotein A-I to render HDL dysfunctional, which results in impaired ABCA1 macrophage transport, the activation of inflammatory pathways, and an increased risk of coronary artery disease. 26323267 2016
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men. 26535656 2015
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE In conclusion, because various genes, LDLR, CETP, APOA5, Apo E, Apo B, and Apo A-I, are associated with the precipitation of CAD associated with T2DM, a personalized diet-gene intervention therapy may be advocated to reduce the disease precipitation. 25470794 2015
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE The individuals with the APOA1 -75 A allele were likely to have a lower risk of CAD as a result of its effect on higher serum concentrations of ApoA1 and HDL-C. 26173491 2015
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Therefore, HDL-C and apoA1 have been investigated as therapeutic targets for coronary heart disease. 24713591 2014
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Furthermore, only mutation carriers with HDLc <5th percentile had elevated risk of CAD (odds ratio (OR)=2.26 for 34 ABCA1 mutation carriers vs. 149 total first-degree relative controls, p=0.05; OR=2.50 for 26 APOA1 mutation carriers, p=0.04; OR=3.44 for 38 LCAT mutation carriers, p=1.1∗10(-3)). 21875686 2012
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE The goal is to identify Apo lipoprotein A1 (APOA1) gene polymorphisms and their association with CAD risk factors, metabolic syndrome and dysfunctional HDL (Dys-HDL). 22297598 2012
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE In large meta-analyses, associations between FADS1-2-3 and carotid intima media thickness, AGPAT1 and type 2 diabetes, and APOA1 and coronary artery disease were observed. 22359512 2012
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Although apolipoprotein A-I protein quantity in EAT was similar between CAD and non CAD patients, its released levels from this fat pad were lower in CAD. 22959663 2012
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE The objective of the current study is to assess the prevalence of metabolic syndrome (MS), its association with high density Lipoprotein (HDL) function, Apo lipoprotein A-I (APOA1) gene polymorphisms, and sub-clinical CAD using common carotid intima-media thickness (CCA-IMT) as a surrogate marker. 21410987 2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE Apolipoprotein A-I (apoA-I) exerts many potentially anti-atherogenic properties and is therefore attractive for prevention and therapy of coronary heart disease. 21930241 2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE APOA1/C3/A4/A5 gene cluster is closely involved in lipid metabolism, and its polymorphisms have been associated with coronary heart disease and lipid plasma levels. 21712729 2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 Biomarker disease BEFREE His elder brother was also homozygous for apoA-I Tomioka with marked HDL cholesterol and apoA-I deficiency, but had no clinical evidence of coronary heart disease. 19473658 2009
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 AlteredExpression disease LHGDN Association between lipoprotein(a) levels, apo(a) isoforms and family history of premature CAD in young Asian Indians. 18280807 2008
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease LHGDN Serum apolipoprotein E and apolipoprotein A1 levels were significantly lower in CAD patients than controls. 18398670 2008
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 AlteredExpression disease BEFREE Serum apolipoprotein E and apolipoprotein A1 levels were significantly lower in CAD patients than controls. 18398670 2008