Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.520 Biomarker disease BEFREE Here we compared younger men (22 ± 2 yr, n = 26), middle-aged men (31 ± 5 yr, n = 35), older men without CAD (60 ± 10 yr, n = 30) and older men with CAD (63 ± 8 yr, n = 30) in terms of testosterone/estradiol ratio, leukocyte telomerase reverse transcriptase (hTERT) expression, activity of telomerase in peripheral blood mononuclear cells (PBMCs), and length of PBMC telomeres. 30179663 2019
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.520 GeneticVariation disease BEFREE The aim of the present study was to determine whether six variants in the TERT gene are associated with risk of incident coronary heart disease, incident ischemic stroke, and mortality in participants in the biracial population-based Atherosclerosis Risk in Communities (ARIC) study, including rs2736100 that was found to influence mean telomere length in a genome-wide analysis. 26201603 2015
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.520 Biomarker disease GENOMICS_ENGLAND Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene. 18042801 2008
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.520 Biomarker disease CTD_human Coronary artery disease and a functional polymorphism of hTERT. 16890917 2006
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.520 Biomarker disease GENOMICS_ENGLAND Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. 15814878 2005
Entrez Id: 6943
Gene Symbol: TCF21
TCF21
0.500 AlteredExpression disease BEFREE In humans, TCF21 expression inhibits risk for CAD. 31815603 2020
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.500 GeneticVariation disease BEFREE Studies have provided controversial results regarding whether variations in the proprotein convertase subtilisin/kexin type 9 gene ( PCSK9) are risk factors for CAD. 30947598 2020
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 Biomarker disease BEFREE The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (I) - Contribution to the Elucidation of the Pathophysiology of Human Hypercholesterolemia and Coronary Heart Disease. 31748469 2020
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE We concluded that the heterozygosity in LDLR-rs72658855and rs2228671 and T allele in LDLR rs2228671are strongly associated with an increased susceptibility to coronary artery disease. 31613733 2020
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipoprotein metabolism that mainly occurs due to mutations in the low-density lipoprotein receptor gene and is characterized by increased levels of low-density lipoprotein cholesterol, leading to accelerated atherogenesis and premature coronary heart disease. 31633867 2020
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.500 AlteredExpression disease BEFREE Few studies have investigated the relationship between PCSK9 levels and the severity of coronary artery disease in patients with acute coronary syndrome; thus, we herein aimed to investigate this relationship in patients with non-ST-elevation myocardial infarction (NSTEMI) who underwent coronary angiography. 31206403 2020
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation disease BEFREE Interaction between eNOS gene polymorphism and current smoking on susceptibility to coronary heart disease in Chinese people. 31567371 2020
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE Elevated lipoprotein(a) [Lp(a)] is an independent risk factor for coronary artery disease (CAD). 30234895 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease GWASCAT A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population. 31186284 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 AlteredExpression disease BEFREE However, clinical impacts of lipoprotein(a) levels on adverse vascular events in patients with established coronary artery disease who are undergoing statin treatment have not been fully elucidated. 31577620 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.500 Biomarker disease BEFREE A significant increase in plasma PCSK9 concentrations was observed with greater CAD severity (p = .042). 31493378 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE Proprotein subtilisin kexin type 9 (PCSK9) and lipoprotein (a) [Lp(a)] levels are causative risk factors for coronary heart disease. 29103916 2019
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE Mutations in the LDLR gene lead to a reduced hepatic clearance of LDL as well as a high risk of coronary artery disease (CAD) and sudden cardiac death (SCD). 31731579 2019
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE The proportion of LDLR pathogenic variants was higher in patients with a younger age of coronary artery disease (CAD) onset and significantly decreased as the age of CAD onset increased. 31491741 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE Lipoprotein(a) and Cardiovascular Outcomes in Patients With Coronary Artery Disease and Prediabetes or Diabetes. 31076417 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.500 GeneticVariation disease BEFREE Although lipid-lowering drugs, especially statins, and recently also PCSK9 inhibitors can reduce LDL cholesterol (LDL-C) and decrease the risk for cardiovascular disease (CVD) including coronary artery disease (CAD) events most efficiently, only 5-10% of high-risk cardiovascular patients reach the target values recommended by international guidelines. 31818446 2019
Entrez Id: 28
Gene Symbol: ABO
ABO
0.500 Biomarker disease BEFREE Coronary Heart Disease and ABO Blood Group in Diabetic Women: A Case-Control Study. 31092877 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE Those with evidence of CAD were significantly more likely to be male, inactive, diabetic and with a family history of CVD than participants without CAD.About 20% of patients had lipoprotein(a) (Lp(a)) concentrations above 106.9 nmol/L (fifth quintile). 31481563 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.500 Biomarker disease BEFREE Cost effectiveness of lifelong therapy with PCSK9 inhibitors for lowering cardiovascular events in patients with stable coronary artery disease: Insights from the Ludwigshafen Risk and Cardiovascular Health cohort. 31207358 2019
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.500 Biomarker disease BEFREE This manuscript mainly reviewed existing evidences suggesting the opposite role of apoC3 and apoA5 in lipid metabolism and CAD risk, and discussed the potential correlation between these two apolipoproteins. 31836003 2019