Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.080 Biomarker disease BEFREE Furthermore, the RPE method revealed that DRB1*03 (χ² = 98.754, <i>p</i> < 0.001), DRB1*04 (χ² = 94.685, <i>p</i> < 0.001), DRB1*09 (χ² = 40.489, <i>p</i> < 0.001), DRB1*01 (χ² = 12.181, <i>p</i> < 0.001), DRB1*07 (χ² = 10.882, <i>p</i> = 0.001), and DRB1*08 (χ² = 5.000, <i>p</i> = 0.025) play protective roles against LADA. 31540313 2019
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.080 Biomarker disease BEFREE Interestingly, the most susceptible T1D haplotypes, DRB1*0901-DQA1*05-DQB1*0201, DRB1*0301-DQA1*03-DQB1*0201, and DRB1*0301-DQA1*03-DQB1*0303, are not associated with LADA. 26866570 2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.080 GeneticVariation disease BEFREE High GAD65Ab titers per se are not a major risk factor for disease progression in LADA, while the number of positive autoantibodies and HLA DRB1-DQB1 genotypes at high risk for T1D are significant predictors. 20603341 2010
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.080 GeneticVariation disease BEFREE The HLA genotyping revealed a significantly higher frequency of HLA DRB1*03 allele in both T1DM and LADA groups when compared to healthy subjects: T1DM (25.7%) vs. control group (10.15%), odds ratio (OR) = 3.06, P < 0.05; LADA (27.6%) vs. control (10.15%), OR = 3.37, P < 0.01. 18279373 2008
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.080 GeneticVariation disease BEFREE These genotypes and those containing DRB1 0401 and DQB1 0302 associated with a younger age at diagnosis in LADA, whereas genotypes containing DRB1 1501 and DQB1 0602 associated with an older age at diagnosis. 17143607 2007
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.080 GeneticVariation disease BEFREE HLA-DRB1 (*)03 has been found as a single risk factor for LADA (P<0.0001, OR=4.9). 17318773 2007
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.080 GeneticVariation disease BEFREE Both type 1 diabetes mellitus and LADA were positively associated with the DRB1*04-DQB1*0302 (DR4/DQ8) haplotype (P=0.00001, and P=0.0005, respectively), and negatively associated with the DRB1*11-DQB1*0301 (DR11/DQ7) haplotype (P=0.00006, and P=0.007, respectively) compared with control population. 12270547 2002
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.080 GeneticVariation disease BEFREE Previous studies have shown that the risk for LADA, similarly to type 1 diabetes mellitus (T1DM), is increased in subjects carrying the HLA-DRB1*03-DQA1*0501-DQB1*0201 and/or HLA-DRB1*04-DQA1*0301-DQB1*0302 haplotypes. 12021137 2002