Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1869
Gene Symbol: E2F1
E2F1
0.040 Biomarker disease BEFREE Our findings show that a high percentage of known HER2+ breast cancer susceptibility genes, including EGFR, IGFR, and E2F1, are under transcriptional control of NRF1. 30128822 2018
Entrez Id: 1869
Gene Symbol: E2F1
E2F1
0.040 AlteredExpression disease BEFREE To investigate the molecular mechanisms associated with the interactions between lapatinib and capecitabine, the effect of treatment with lapatinib and phosphatidylinositol‑4,5‑bisphosphate 3‑kinase (PI3K) inhibitors on the expression of E2F transcription factor 1 (E2F1) and thymidylate synthase (TS), which is associated with an increased response to 5‑fluorouracil (5‑FU)‑based chemotherapy, was determined in HER2‑positive breast cancer cells. 29845287 2018
Entrez Id: 1869
Gene Symbol: E2F1
E2F1
0.040 Biomarker disease BEFREE Previously, we demonstrated that silencing E2F1 or E2F3 suppresses centrosome amplification (CA) and chromosome instability (CIN) in Her2+ breast cancer cells without markedly altering proliferation. 26512919 2015
Entrez Id: 1869
Gene Symbol: E2F1
E2F1
0.040 Biomarker disease BEFREE We also predict KIF2C is a target gene for ER-/HER2- breast cancer and is positively regulated by E2F1. 23610368 2013