Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE TLX1- or TLX3-deregulated T-cell acute lymphoblastic leukemias (T-ALL; TLX1/3<sup>+</sup>) share an immature cortical phenotype and similar transcriptional signatures. 30659025 2019
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia. 30107177 2018
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 AlteredExpression disease BEFREE T-cell acute lymphoblastic leukemia (T-ALL) results from leukemic transformation of T-cell precursors arrested at specific differentiation stages, including an 'early-cortical' thymic maturation arrest characterized by expression of cytoplasmic TCRβ but no surface T-cell receptor (TCR) and frequent ectopic expression of the TLX1/3 NK-like homeotic proteins (NKL). 28592888 2018
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE Here, we used chromatin immunoprecipitation followed by sequencing to establish the genome-wide binding pattern of TLX1 in human T-ALL. 26108691 2015
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 FusionGene disease ORPHANET TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression. 22516263 2012
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 AlteredExpression disease BEFREE Overall, these results place TLX1 and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, show the power of network analyses to identify key elements in the regulatory circuits governing human cancer and identify RUNX1 as a tumor-suppressor gene in T-ALL. 22366949 2012
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 FusionGene disease ORPHANET Hijacking T cell differentiation: new insights in TLX function in T-ALL. 22516255 2012
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 GeneticVariation disease BEFREE The most common recurrent cytogenetic abnormalities in T-lymphoblastic leukemia (T-acute lymphoblastic leukemia [T-ALL]) involve T-cell receptor (TCR) loci and a variety of partner genes, including HOX11, HOX11L2, MYC, and TAL1. 22563559 2012
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphoma. 21326611 2011
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 GeneticVariation disease BEFREE Importantly, the disruption of the mitotic checkpoint in TLX1-induced tumors may be linked not only to the acquisition of secondary genetic alterations in T-ALL but also to increased sensitivity of these tumors to chemotherapy with drugs targeting the formation of the mitotic spindle. 21705452 2011
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 AlteredExpression disease BEFREE These cases generally lacked overexpression of the TAL1, HOX11, HOX11L2, or the HOXA cluster genes, which have been used to define separate molecular pathways leading to T-ALL. 20124220 2010
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 GeneticVariation disease BEFREE Mutually exclusive oncogenic rearrangements may delineate specific T-cell acute lymphoblastic leukaemia (T-ALL) subgroups, and so far at least 4 molecular-cytogenetic subgroups have been identified, i.e. the TAL/LMO, the TLX1/HOX11, the TLX3/HOX11L2 and the HOXA subgroups. 21112032 2010
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 AlteredExpression disease BEFREE Here, we report that TLX1 and MEIS proteins both interact and are co-expressed in T-ALL, and suggest that co-operation between TLX1 and MEIS proteins may have a significant role in T-cell leukemogenesis. 19559479 2010
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease CTD_human Here we show that transgenic expression of human TLX1 in mice induces T-ALL with frequent deletions and mutations in Bcl11b (encoding B cell leukemia/lymphoma-11B) and identify the presence of recurrent mutations and deletions in BCL11B in 16% of human T-ALLs. 20972433 2010
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE Understanding the processes involved in TLX1-mediated cellular immortalization should yield insights into the growth and differentiation pathways altered by TLX1 during the development of T-ALL. 19862821 2010
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 AlteredExpression disease BEFREE We found that TLX1 and NOTCH synergistically regulate transcription in T-ALL, at least in part via the sharing of a TLE corepressor and by augmenting expression of MYC. 20618946 2010
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE Three members of the NK-like subfamily of homeobox genes (NKLs), TLX1, TLX3 and NKX2-5, are implicated in T-cell acute lymphoblastic leukemia (T-ALL). 19835636 2009
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemia (T-ALL), leading to differentiation arrest and cell transformation. 17934490 2007
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE We propose that TLX1(+) T-ALLs be defined as cases expressing TLX1/ABL ratios greater than 1 and/or demonstrating TLX1 rearrangement. 17609427 2007
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 AlteredExpression disease BEFREE HOX11 overexpression may correlate with a good prognosis in adult pre-T ALL. 17369128 2007
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE Loss or reduced levels of Ubr1 expression was associated with 5/14 spontaneous B-cell lymphomas in IgHmu-HOX11(Tg) mice and one of nine primary human T-ALLs. 16862188 2006
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE The relevance of these findings is discussed in the context of activating NOTCH1 mutations and the other genetic lesions implicated in the multistep transformation process of TLX1(+) T-ALL. 16398656 2006
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 GeneticVariation disease BEFREE Dysregulated expression of the homeobox gene, HOX11 is a frequent etiologic event in T-cell acute lymphoblastic leukemias. 16407851 2006
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE The majority of patients with HOX11 T-ALL underwent allografting, predominantly in second CR, but were not associated with a superior OS. 15637138 2005
Entrez Id: 3195
Gene Symbol: TLX1
TLX1
0.600 Biomarker disease BEFREE Here, we employed oligonucleotide microarrays to compare the expression profiles of the K3P and Sil leukemic cell lines originating from patients with HOX11+ T-ALL to that of Jurkat cells, which originated from a distinct subtype of T-ALL (TAL1+). 15897879 2005