Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.380 | GeneticVariation | disease | BEFREE | Approximately 8% of childhood T-ALL cases have rearrangements involving the ABL1 tyrosine kinase gene at 9q34.12; although a t(9;22), resulting in a fusion of ABL1 with the BCR gene at 22q11.23 is a common occurrence in B-ALL, it is not a typical finding in T-ALL. | 30803551 | 2019 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | We present the first case of T acute lymphoblastic leukemia with a t(4;22)(q12;q11.2) involving the BCR and PDGFRA genes, without associated eosinophilia. | 26095243 | 2015 | ||||
|
0.380 | Biomarker | disease | BEFREE | The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is rare in T-cell acute lymphoblastic leukemia (T-ALL). | 15713800 | 2005 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Here we report the identification of an oligopurine/oligopyrimidine DNA in the t(10;14) breakpoint cluster region associated with T-cell acute lymphoblastic leukemia. | 1741251 | 1992 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | The t(10;14)(q24;q11) chromosomal translocation found in malignant cells of 5-10% of patients with T-cell acute lymphoblastic leukemia (T-ALL) involves the T-cell receptor delta chain gene on chromosome 14 and a breakpoint cluster region on chromosome 10. | 1717256 | 1991 | ||||
|
0.380 | Biomarker | disease | BEFREE | One case of de novo Ph-negative T-cell acute lymphoblastic leukaemia has been found to have a classical breakpoint cluster region (bcr) rearrangement of the type seen in chronic granulocytic leukaemia. | 2304357 | 1990 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | It defines a new locus in 11p13-delta J, which is close to the Wilms tumor gene and the breakpoint cluster region (TCL2) of the frequent t(11;14)(p13;q11) translocation in acute T-cell leukemia. | 2574149 | 1989 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Finally, comparison of the breakpoint in band 11p13 with those of other translocations (11;14)(p13;q11) identified a breakpoint cluster region of approximately 1.2 kilobase-pairs (kb), alterations of which may promote the development of T-ALL. | 2526665 | 1989 | ||||
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0.380 | FusionGene | disease | ORPHANET |