Gene: SET ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6418
Gene Symbol: SET
SET 		0.370 FusionGene disease ORPHANET Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia. 29279377 2018
Entrez Id: 6418
Gene Symbol: SET
SET 		0.370 Biomarker disease BEFREE Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia. 27705940 2016
Entrez Id: 6418
Gene Symbol: SET
SET 		0.370 Biomarker disease BEFREE SET-NUP214-positive patients were predominantly (10 [91%] of 11) T-cell receptor (TCR)-negative and strikingly associated with TCRγδ lineage T-ALLs, as defined by expression of TCRγδ, TCRδ and/or TCRγ rearrangements but no complete TCRβ variable diversity joining rearrangement in surface CD3/TCR-negative cases. 24449214 2014
Entrez Id: 6418
Gene Symbol: SET
SET 		0.370 AlteredExpression disease BEFREE We showed that SET expression was significantly upregulated in 96.5% of B-acute lymphoblastic leukemia (28 of 29; 16.6 fold) and 93% of T-acute lymphoblastic leukemia (28 of 30; 47.6 fold) patients. 22677993 2012
Entrez Id: 6418
Gene Symbol: SET
SET 		0.370 GeneticVariation disease BEFREE Overall, these results indicate that, in T-cell acute lymphoblastic leukemia, PHF6 mutations are a recurrent genetic abnormality associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214. 21880637 2011
Entrez Id: 6418
Gene Symbol: SET
SET 		0.370 Biomarker disease BEFREE Multiplex-polymerase chain reaction analysis and gene expression profiling of 129 further cases found five additional cases of TAF_I-NUP214-positive T-cell acute lymphoblastic leukemia. 20065082 2010
Entrez Id: 6418
Gene Symbol: SET
SET 		0.370 AlteredExpression disease BEFREE Of 141 human leukemia/lymphoma cell lines tested, only the T-ALL cell line LOUCY and the AML cell line MEGAL expressed the SET(TAF-Ibeta)-NUP214 fusion gene transcript. 19166587 2009
Entrez Id: 6418
Gene Symbol: SET
SET 		0.370 Biomarker disease BEFREE We conclude that SET-NUP214 may contribute to the pathogenesis of T-ALL by enforcing T-cell differentiation arrest. 18299449 2008