×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
LHGDN
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.
17910045
2008
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
BEFREE
The mutational spectrum of FLT3 gene in acute lymphoblastic leukemia is different from acute myeloid leukemia.
31285539
2020
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
UNIPROT
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
BEFREE
High FLT3 expression and IL10 (G1082A ) polymorphism in poor overall survival in calla acute lymphoblastic leukemia .
23086275
2013
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
LHGDN
Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias.
15044257
2004
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
BEFREE
Impact of mutations in FLT3 , PTPN11 and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil.
24067137
2014
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
BEFREE
FLT3 mutations in canine acute lymphocytic leukemia .
21272320
2011
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
LHGDN
FLT3 mutations in childhood acute lymphoblastic leukemia.
14670924
2004
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
BEFREE
The present study employed single cell mutation analysis to evaluate the FLT3 -ITD status in newly diagnosed acute myeloid leukemia (n = 5) and acute lymphocytic leukemia (n = 3) patients.
24495871
2014
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
BEFREE
Two of 25 ALL patients (8%) showed a mutated band of FLT3 -ITD mutation representing 12.5% of pediatric patients, and all the other ALL cases showed the absence of this mutation.
24390456
2014
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
GWASDB
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.
19684604
2009
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
BEFREE
The impact of IKZF1 deletion on the prognosis of acute lymphoblastic leukemia : an updated meta-analysis.
25335741
2014
×
Entrez Id:
5079
Gene Symbol:
PAX5
PAX5
0.700
GeneticVariation
disease
BEFREE
PAX5 deletions are frequent in adult BCR-ABL1-positive acute lymphoblastic leukemia and are not associated with a poor outcome.
20534699
2010
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
BEFREE
Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.
27979924
2017
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
BEFREE
Ikaros (IKZF1 ) alterations and minimal residual disease at day 15 assessed by flow cytometry predict prognosis of childhood BCR/ABL-negative acute lymphoblastic leukemia .
22997141
2013
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
BEFREE
The genomic profile of ETV6-ABL1 acute lymphoblastic leukemia resembled that of BCR-ABL1 and BCR-ABL1-like cases with 80% of patients having concurrent CDKN2A/B and IKZF1 deletions.
27229714
2016
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
BEFREE
IKZF1 deletion and co-occurrence with other aberrations in a child with chronic myeloid leukemia progressing to acute lymphoblastic leukemia .
30511400
2019
×
Entrez Id:
5079
Gene Symbol:
PAX5
PAX5
0.700
GeneticVariation
disease
BEFREE
PAX5 , a transcription factor pivotal for B-cell commitment and maintenance, is one of the most frequent targets of somatic mutations in B-cell precursor acute lymphoblastic leukemia .
24435167
2014
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
BEFREE
Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia : an international collaborative study.
26202931
2016
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
GWASCAT
GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21.
29348612
2018
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
BEFREE
IKZF1 rs4132601 polymorphism and acute lymphoblastic leukemia susceptibility: a meta-analysis.
25012940
2015
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
BEFREE
Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia .
29507076
2018
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
BEFREE
IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia .
30877974
2019
×
Entrez Id:
5079
Gene Symbol:
PAX5
PAX5
0.700
GeneticVariation
disease
BEFREE
IKZF1 and PAX5 deletions were observed in 13 and 17% of B-LBL, respectively, which was similar to the reported frequency in B-ALL .
27957801
2017
×
Entrez Id:
10320
Gene Symbol:
IKZF1
IKZF1
0.700
GeneticVariation
disease
BEFREE
In conclusion, the need of and benefit from introducing IKZF1 deletions as an additional stratification marker for patients with Philadelphia-negative B-cell precursor acute lymphoblastic leukemia remain questionable.
23585525
2013