×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
Biomarker
disease
CTD_human
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
UNIPROT
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
CausalMutation
disease
CGI
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
Biomarker
disease
HPO
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
BEFREE
<b>Purpose:</b> The FLT3 cell-surface receptor tyrosine kinase (CD135 ) is expressed in a majority of both acute lymphoid leukemia (ALL ) and myeloid leukemia (AML).
28108543
2017
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
BEFREE
FLT3 is widely expressed in AML and some cases of acute lymphocytic leukemia .
15604885
2005
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
LHGDN
FLT3 is widely expressed in AML and some cases of acute lymphocytic leukemia .
15604885
2005
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
BEFREE
Fms-like tyrosine kinase 3 (FLT3 ) is highly expressed in acute lymphoblastic leukemia with the mixed-lineage leukemia (MLL) gene rearrangement refractory to chemotherapy.
17942916
2007
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
Biomarker
disease
BEFREE
FLT3 /ITDs in the juxtamembrane domain were found in 25% of patients with acute myeloid leukemia and 7% of patients with acute lymphoid leukemia .
18925699
2008
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
BEFREE
FLT3 mutations in canine acute lymphocytic leukemia .
21272320
2011
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
BEFREE
FLT3 is expressed at high levels in 70-100% of cases of AML and in virtually all cases of B-lineage acute lymphoblastic leukemia .
22049994
2012
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
BEFREE
Fms-like tyrosine kinase 3 (FLT3 ) is highly expressed in mixed-lineage leukemia (MLL) gene-rearranged acute lymphoblastic leukemia (MLL+ALL) with a dismal prognosis.
28917156
2017
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
LHGDN
Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias.
15044257
2004
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
BEFREE
Although FLT3 mutations are essentially found in myeloid-lineage leukemia cells, a high level of FLT3 expression was recently observed in MLL gene-rearranged acute lymphoblastic leukemia without FLT3 mutations.
14604973
2004
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
Biomarker
disease
BEFREE
Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia .
27181063
2016
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
LHGDN
FLT3 mutations in childhood acute lymphoblastic leukemia.
14670924
2004
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
BEFREE
High FLT3 expression and IL10 (G1082A ) polymorphism in poor overall survival in calla acute lymphoblastic leukemia .
23086275
2013
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
BEFREE
Impact of mutations in FLT3 , PTPN11 and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil.
24067137
2014
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
BEFREE
In leukemia, FLT3 was found to be significantly upregulated in acute myeloid leukemia and acute lymphoblastic leukemia , and a high expression of FLT3 contributed to reduced survival rates.
29257272
2018
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
LHGDN
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.
17910045
2008
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
BEFREE
Our previous data demonstrated specific up-regulation of miR-155 in FLT3 -ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia .
26055960
2015
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
BEFREE
Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia .
22705992
2012
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
AlteredExpression
disease
LHGDN
Prognostic significance of high-level FLT3 expression in MLL-rearranged infant acute lymphoblastic leukemia .
17881645
2007
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
Biomarker
disease
BEFREE
The incorporation of ABL kinase inhibitors into acute lymphoblastic leukemia management should serve as a model for incorporation of FLT3 -targeted agents into clinical care.
24468836
2014
×
Entrez Id:
2322
Gene Symbol:
FLT3
FLT3
0.800
GeneticVariation
disease
BEFREE
The mutational spectrum of FLT3 gene in acute lymphoblastic leukemia is different from acute myeloid leukemia.
31285539
2020