Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 GeneticVariation disease BEFREE The mutational spectrum of FLT3 gene in acute lymphoblastic leukemia is different from acute myeloid leukemia. 31285539 2020
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease BEFREE In leukemia, FLT3 was found to be significantly upregulated in acute myeloid leukemia and acute lymphoblastic leukemia, and a high expression of FLT3 contributed to reduced survival rates. 29257272 2018
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease BEFREE Fms-like tyrosine kinase 3 (FLT3) is highly expressed in mixed-lineage leukemia (MLL) gene-rearranged acute lymphoblastic leukemia (MLL+ALL) with a dismal prognosis. 28917156 2017
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease BEFREE <b>Purpose:</b> The FLT3 cell-surface receptor tyrosine kinase (CD135) is expressed in a majority of both acute lymphoid leukemia (ALL) and myeloid leukemia (AML). 28108543 2017
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 Biomarker disease BEFREE Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia. 27181063 2016
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease BEFREE Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia. 26055960 2015
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 Biomarker disease BEFREE The incorporation of ABL kinase inhibitors into acute lymphoblastic leukemia management should serve as a model for incorporation of FLT3-targeted agents into clinical care. 24468836 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 GeneticVariation disease BEFREE Impact of mutations in FLT3, PTPN11 and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil. 24067137 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 GeneticVariation disease BEFREE The present study employed single cell mutation analysis to evaluate the FLT3-ITD status in newly diagnosed acute myeloid leukemia (n = 5) and acute lymphocytic leukemia (n = 3) patients. 24495871 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 GeneticVariation disease BEFREE Two of 25 ALL patients (8%) showed a mutated band of FLT3-ITD mutation representing 12.5% of pediatric patients, and all the other ALL cases showed the absence of this mutation. 24390456 2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 GeneticVariation disease BEFREE High FLT3 expression and IL10 (G1082A) polymorphism in poor overall survival in calla acute lymphoblastic leukemia. 23086275 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease BEFREE To further explore the efficacy of targeted therapies, we demonstrate that T-ALL cell lines transfected with FLT3 expression constructs were particularly sensitive to tyrosine kinase inhibitors. 23359050 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease BEFREE Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia. 22705992 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease BEFREE FLT3 is expressed at high levels in 70-100% of cases of AML and in virtually all cases of B-lineage acute lymphoblastic leukemia. 22049994 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 GeneticVariation disease BEFREE FLT3 mutations in canine acute lymphocytic leukemia. 21272320 2011
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 GeneticVariation disease LHGDN Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. 17910045 2008
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 Biomarker disease BEFREE FLT3/ITDs in the juxtamembrane domain were found in 25% of patients with acute myeloid leukemia and 7% of patients with acute lymphoid leukemia. 18925699 2008
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease LHGDN We will highlight the role of FLT3 in hematopoiesis, and how when activated, it may play a role in the development of acute myeloid or acute lymphoblastic leukemia. 17584026 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease LHGDN Prognostic significance of high-level FLT3 expression in MLL-rearranged infant acute lymphoblastic leukemia. 17881645 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease BEFREE Fms-like tyrosine kinase 3 (FLT3) is highly expressed in acute lymphoblastic leukemia with the mixed-lineage leukemia (MLL) gene rearrangement refractory to chemotherapy. 17942916 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease BEFREE FLT3 is widely expressed in AML and some cases of acute lymphocytic leukemia. 15604885 2005
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease LHGDN FLT3 is widely expressed in AML and some cases of acute lymphocytic leukemia. 15604885 2005
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 AlteredExpression disease BEFREE Although FLT3 mutations are essentially found in myeloid-lineage leukemia cells, a high level of FLT3 expression was recently observed in MLL gene-rearranged acute lymphoblastic leukemia without FLT3 mutations. 14604973 2004
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 GeneticVariation disease LHGDN Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias. 15044257 2004
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
0.800 GeneticVariation disease LHGDN FLT3 mutations in childhood acute lymphoblastic leukemia. 14670924 2004