×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
MLL rearrangements are translocation mutations that cause both acute lymphoblastic leukemia and acute myeloid leukemia (AML).
31405949
2019
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
PosttranslationalModification
disease
BEFREE
Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL -rearranged acute lymphoblastic leukemia .
31395602
2019
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
Except for one case with biallelic KMT2A (MLL ) breaks, all cases analyzed by FISH lacked the most common translocations defining molecular subsets of lymphoblastic leukemia /lymphomas.
30578714
2019
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
We report BU PK data on HSCT conditioning for infants with KMT2A -gene-rearrangement-positive acute lymphoblastic leukemia (MLL -r ALL).
31201644
2019
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
Chemosensitivity is differentially regulated by the SDF-1/CXCR4 and SDF-1/CXCR7 axes in acute lymphoblastic leukemia with MLL gene rearrangements.
30453100
2018
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
Frequency and prognostic significance of t(v;11q23)/KMT2A rearrangements in adult patients with acute lymphoblastic leukemia treated with risk-adapted protocols.
27122129
2017
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
In this case study, we diagnosed t-MN with KMT2A rearrangement in a patient with history of B-ALL with 9p deletion and gain of X chromosome.
29155023
2017
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
BEFREE
Mutations in <i>SETD2</i><i>,</i> encoding the histone 3 lysine 36 trimethyltransferase, are enriched in relapsed acute lymphoblastic leukemia and MLL -rearranged acute leukemia.
29018079
2017
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
TGFβ1 synergizes with FLT3 ligand to induce chemoresistant quiescence in acute lymphoblastic leukemia with MLL gene rearrangements.
28917156
2017
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
Haploidentical peripheral blood stem cell transplantation without irradiation or busulfan after reduced-intensity conditioning for KMT2A (MLL)-rearranged infant B-cell precursor acute lymphoblastic leukemia : Report of two cases.
28332262
2017
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
BEFREE
Amlexanox Downregulates S100A6 to Sensitize <i>KMT2A /AFF1</i>-Positive Acute Lymphoblastic Leukemia to TNFα Treatment.
28646023
2017
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
BEFREE
Azacitidine successfully maintained the second remission in an infant with KMT2A -rearranged acute lymphoblastic leukemia who relapsed after unrelated cord blood transplantation.
28675638
2017
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
CTD_human
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.
25730765
2015
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
We present a case of an infant with bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement.
25493458
2015
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
BEFREE
In non-DS, frequent abnormalities were MLL rearrangements, mainly MLL-AFF1 in acute lymphoblastic leukemia and MLL -MLLT3 in AML.
24991719
2015
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
BEFREE
Favorable outcome in non-infant children with MLL -AF4-positive acute lymphoblastic leukemia : a report from the Tokyo Children's Cancer Study Group.
26410102
2015
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
BEFREE
Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL -rearranged acute lymphoblastic leukemia .
25793396
2015
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement: Single institution experience and the review of the literature.
26259760
2015
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
Early use of allogeneic hematopoietic stem cell transplantation for infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia .
24888273
2015
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
CTD_human
Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements.
24736461
2014
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements.
24736461
2014
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
BEFREE
Depletion of JMJD1C impairs expansion and colony formation of human leukemic cell lines, with the strongest effect observed in the MLL -rearranged ALL cell line SEM.
24501218
2014
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
BEFREE
CDKN1A-mediated responsiveness of MLL -AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors.
24382688
2014
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
Biomarker
disease
BEFREE
MLL partner genes in secondary acute lymphoblastic leukemia : report of a new partner PRRC1 and review of the literature.
25205603
2014
×
Entrez Id:
4297
Gene Symbol:
KMT2A
KMT2A
0.400
GeneticVariation
disease
BEFREE
The role of MLL gene deregulation in rare cases of isolated lymphoblastic lymphoma in infants is obscure.
24635731
2014