| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.460 | GeneticVariation | disease | BEFREE | The most common recurrent cytogenetic abnormalities in T-lymphoblastic leukemia (T-acute lymphoblastic leukemia [T-ALL]) involve T-cell receptor (TCR) loci and a variety of partner genes, including HOX11, HOX11L2, MYC, and TAL1. | 22563559 | 2012 | ||||
|
0.460 | AlteredExpression | disease | BEFREE | T cell lymphoblastic leukemia (T-ALL) is known to be associated with chromosomal abnormalities that lead to aberrant expression of a number of transcription factors such as TAL1, which dimerizes with basic helix-loop-helix (bHLH) E proteins and inhibits their function. | 22393458 | 2012 | ||||
|
0.460 | GeneticVariation | disease | LHGDN | Does TAL-1 deletion contribute to the high incidence of T-cell acute lymphoblastic leukemia in South Indian patients? | 18439091 | 2009 | ||||
|
0.460 | GeneticVariation | disease | BEFREE | Quantification of minimal residual disease in T-lineage acute lymphoblastic leukemia with the TAL-1 deletion using a standardized real-time PCR assay. | 11243385 | 2001 | ||||
|
0.460 | GeneticVariation | disease | BEFREE | Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets: report of the BIOMED-1 CONCERTED ACTION: investigation of minimal residual disease in acute leukemia. | 10049045 | 1999 | ||||
|
0.460 | GeneticVariation | disease | BEFREE | Additionally, scl gene disruption and dysregulation, by either chromosomal translocations or a site-specific interstitial deletion whereby 5' regulatory elements of the sil gene become juxtaposed to the body of the scl gene, is associated with T-cell acute lymphoblastic leukemia (ALL) and T-cell lymphoblastic lymphoma. | 9171354 | 1997 | ||||
|
0.460 | Biomarker | disease | HPO | |||||||
|
0.460 | Biomarker | disease | CTD_human |