Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE RAS and TP53 can predict survival in adults with T-cell lymphoblastic leukemia treated with hyper-CVAD. 31804006 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE In TP53 mutated acute lymphoblastic leukemia, APR-246 induced apoptosis showing strong anti-leukemia activity. 31073076 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE TP53 mutation does not confer a poor outcome in adult patients with acute lymphoblastic leukemia who are treated with frontline hyper-CVAD-based regimens. 28608976 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Inactivated genes, such as <i>ASPP1, TP53, IKZF1</i> and <i>P15</i>, may correlate with poor prognosis in acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL), chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML), respectively. 28580304 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%. 24619868 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Identification of TP53 as an acute lymphocytic leukemia susceptibility gene through exome sequencing. 23255406 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease CTD_human The genomic landscape of hypodiploid acute lymphoblastic leukemia. 23334668 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 PosttranslationalModification disease BEFREE Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia. 21386967 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation. 20658636 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia. 19586936 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 PosttranslationalModification disease BEFREE ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. 16314841 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease LHGDN Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia. 15878620 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE However, such transgenic mice developed thymic lymphoblastic lymphoma when crossed with p53 null mice. 16261166 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Marked overexpression was found in two cases of T-cell prolymphocytic leukemias and in four B-cell lineage acute lymphoblastic leukemia including one case with the t(8;14) and another case with a p53 mutation. 12969807 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells. 14559824 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia. 12375054 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE In the present study, protein expressions of MDM2 and p53 were investigated by immunohistochemistry from bone marrow samples in 23 patients with acute lymphoblastic leukemia aged 1-13 years at diagnosis. p53 protein overexpression was detected in only one case, while overexpression of MDM2 was detected in samples from five patients. 9842645 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Mutational analysis of p53 in 16 cases of acute lymphoblastic leukemia and Burkitt's lymphoma. 9407719 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Frequent p53 mutation in relapsed acute lymphoblastic leukemia with cytogenetic instability: a longitudinal analysis. 9615800 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations. 7605998 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: a report of 48 cases. 7707106 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Mutations of the p53 and ras genes in childhood t(1;19)-acute lymphoblastic leukemia. 7727782 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE The p53 gene was examined in primary lymphoblasts of 25 pediatric patients with acute lymphoblastic leukemia by the RNase protection assay and by single strand conformation polymorphism analysis in 23 of 25 cases. p53 mutations were found to occur, but at a low frequency (4 of 25). 1737852 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene. 1727382 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Fourteen patients with various leukemias were examined and two with acute lymphoblastic leukemia and one with Waldenström's macroglobulinemia were identified to have mutations in the coding region of the p53 gene. 1705829 1991