Suppression of miR-96 expression inhibits the invasion of HCC cells, suggesting that miR-96 may be a therapeutic target for inhibiting HCC invasion and metastasis.
Bladder cancer, lung cancer and hepatocellular carcinoma were the third most frequently reported cancer types with significant over-expression of miR-96, miR-182 and miR-183 respectively.
Our data show that miR-19a and miR-96, whose expression is regulated by ANT2 suppression, were markedly upregulated in HCC cell lines and clinical samples.
The present study indicated that certain miRNAs (including <i>miR-96, miR-145</i> and <i>miR-183</i>) and mRNAs (including <i>NAT2, FBXO5, CCNB1, DEPDC1</i> and <i>NTN4</i>) may be associated with the effects of ribavirin on HCC.
The present study revealed that a LINC01093/miR-96-5p/ZFAND5/NF-κB signaling axis may have an important role in the pathogenesis of HCC, and further investigation of this axis may provide novel insight into the development and progression of HCC.