Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Activation of the PI3K/Akt/mTOR pathway is an important signaling mechanism involved in the development and the progression of liver cancer stem cell (LCSC) population during acquired Sorafenib resistance in advanced hepatocellular carcinoma (HCC). 31439713 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE Mechanistically, overexpression (or silence) of BZW2 in HCC cells significantly stimulates (or decreases) the activation of the PI3K/AKT/mTOR signaling pathway, which is responsible for HCC progression. 30805927 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE NCAPG functions as an oncogene in HCC and plays a role in promoting cell proliferation and antiapoptosis through activating the PI3K/AKT/FOXO4 pathway. 31802891 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Further investigation revealed that PI3K/AKT signalling pathway activation was involved in the oncogenic functions of circ-IGF1R in HCC. 31377314 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Pathway analysis suggested that putative target genes of these essential miRNAs were involved in HCC-associated signaling pathways, such as Wnt, TGF-β, and Ras; whereas protein-protein network (PPI) analysis demonstrated that some validated target genes of these miRNAs, such as PIK3CA, AKT1, MYC, JUN, SMAD4, and SRC, were hub target genes as they have more counts of interacting protein. 31293639 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE PKI-587 enhances chemosensitivity of oxaliplatin in hepatocellular carcinoma through suppressing DNA damage repair pathway (NHEJ and HR) and PI3K/AKT/mTOR pathway. 31497229 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Anemoside B4 exerts anti-cancer effect by inducing apoptosis and autophagy through inhibiton of PI3K/Akt/mTOR pathway in hepatocellular carcinoma. 31105864 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE Moreover, hesperidin administration suppressed DEN-induced upregulation of PI3K, Akt, CDK-2 protein expression, and preserved the integrity of the liver tissues from HCC formation. 30779474 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE Mechanistically, it was found that overexpression of miR-2053 resulted in the downregulation of the phosphoinositide 3-kinase (PI3K) and Wnt/β-catenin signaling pathways, which are aberrantly expressed in HCC. 31423276 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE MenSCs exert an inhibitory effect on HCC growth via regulating 5-hmC and 5-mC abundance in the regulatory regions of oncogenic pathways including PI3K/AKT and MAPK signaling, especially in enhancers and promoters. 31151404 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Pharmacological targeting of APLN by ML221 was safe and effective in inhibiting APLN-PI3K/Akt cascade and HCC growth <i>in vitro</i> and <i>in vivo</i>. 31410213 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma. 31694662 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE These findings reveal that Tmod3 enhances aggressive behavior of HCC both in vitro and in vivo by interacting with EFGR and by activating the PI3K-AKT signaling pathway. 31313392 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Tanshinol exerts its anti-cancer effects via regulating the PI3K-AKT signaling pathway in HCC. 30588033 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE There were 19 HCCs with PIK3CA amplification. 31126975 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE Based on Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PI3K/AKT signaling pathway was significantly upregulated in HCC. 30696802 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE Additionally, 5-HT1D could attenuate tryptophan hydroxylase 1 expression through the PI3K/Akt/cut-like homeobox 1 axis in HCC. 30561038 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE IL-8 siRNA transfection reduced HCC cell invasion and the levels of integrin β3, p-PI3K and p-Akt. 31684995 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K/Akt pathway. 29530052 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells. 30026540 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE We previously showed that inhibition of phosphoinositide 3-kinase (PI3K) abrogated Mt expression and metal-induced MTF-1 activation in human hepatocellular carcinoma (HCC) HepG2 and mouse L cells, thus showing that the PI3K signaling pathway positively regulates MTF-1 activity and Mt gene expression. 29707960 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Secretory Clusterin Mediates Oxaliplatin Resistance via the Gadd45a/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma. 29721050 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Conclusion Moderate heat stress and laser thermal ablation induce hepatocellular carcinoma growth, which is prevented with adjuvant PI3K/mTOR/protein kinase B inhibition. 29737948 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE CONCLUSIONS Up-regulation of PRL-3 may activate the PI3K/AKT signaling pathway and enhance malignant progression of HCC through targeting PTEN. 30418964 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE Furthermore, miR-337 overexpression inhibited the activation of PI3K/AKT and Wnt/β-catenin signaling pathways in HCC both in vitro and in vivo. 29636997 2018