Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation disease BEFREE Moreover, the effects of OCPs exposure on HCC risk are more pronounced amongst GSTP1 (Ile/Val + Val/Val) and GSTP1 promoter methylation subjects than those who were GSTP1 (Ile/Ile) and unmethylated subjects. 31731000 2020
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 AlteredExpression disease BEFREE These results suggest high GSTP1 levels provide a better prognosis through suppression of tumorigenesis in HCC. 29507666 2018
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker disease BEFREE GSTP1 is a largely investigated tissue biomarker in several malignancies such as prostate, breast, lung and hepatocellular carcinoma with good performances especially for diagnostic purposes. 29305565 2018
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification disease BEFREE Compared with normal liver tissue and cirrhosis, the pooled ORs of GSTP1 promoter region methylation in HBV-related HCC cancer tissues were 6.05 (95% CI =1.20-30.52) and 5.21 (95% CI =2.19-12.41), respectively. 30254471 2018
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification disease BEFREE The results of this meta-analysis suggest that GSTP1 hypermethylation induces the inactivation of GSTP1 gene, plays an important role in hepatocarcinogenesis, and is associated with an increased risk of HCC. 29970711 2018
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation disease BEFREE Conclusively, our findings provide supporting evidence for a contributory role of GSTP1 rs4147581 polymorphism in predicting the prognosis of HCC. 26260272 2016
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 AlteredExpression disease BEFREE Further analyses using methylation-specific PCR, combined with expression analysis, in the validation set of primary HCC showed that, in addition to three known tumor-suppressor genes (APC, CDKN2A, and GSTP1), eight genes (AKR1B1, GRASP, MAP9, NXPE3, RSPH9, SPINT2, STEAP4, and ZNF154) were significantly hypermethylated and downregulated in the HCC tumors compared to the non-tumor liver tissues. 26883180 2016
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation disease BEFREE Individuals carrying the Ile/Val genotype of GSTP1 had a significant increased risk of HCC (OR of 2.2, 95 % CI 1.143-4.261) and had larger tumor size. 27271262 2016
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker disease BEFREE Polymorphisms in GSTM1, GSTP1, and GSTO1 enzymes increase the risk of developing breast cancer and hepatocellular carcinoma. 26682223 2015
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker disease BEFREE Under abnormal conditions the excessive reactive oxygen species generation results in genetic predisposition of various genes (as ADH, ALDH, CYP2E1, GSTT1, GSTP1 and GSTM1) involved in xenobiotic metabolic pathways, associated with susceptibility to different liver related diseases such as fibrosis, cirrhosis and hepatocellular carcinoma. 26163595 2015
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation disease BEFREE Two SNPs (GSTO2: rs7085725 and GSTP1: rs4147581) were significantly associated with overall survival in HCC patients (P = 0.035 and 0.042, respectively). 25892883 2015
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker disease BEFREE Our meta-analysis suggested strong associations between APC, GSTP1 and SOCS1 gene promoter methylation and the risk of HCC, suggesting these to be promising biomarkers for HCC. 25853848 2015
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 AlteredExpression disease BEFREE The promoter methylation status of ELF, RASSF1A, p16, and GSTP1 was investigated by methylation-specific polymerase chain reaction (PCR) in 34 paired HCC and nontumor liver tissue from HCC patients and 10 tissues from patients with liver cirrhosis (LC). 25923138 2015
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification disease BEFREE The results indicate a significant association between GSTP1 methylation and poor outcomes in HCC patients. 26125884 2015
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 AlteredExpression disease BEFREE The GSTP1 mRNA expression of HCC patients was also decreased compared with CHB patients (P<0.05). 23569432 2013
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation disease BEFREE In conclusion, the meta-analysis suggests that there is little evidence for the association between GSTP1 Ile105Val polymorphism and hepatocellular carcinoma risk. 23765758 2013
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation disease BEFREE Encouragingly, 33.8% of the AFP-negative HCC contained the methylated GSTP1 gene. 22536438 2012
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation disease BEFREE Individuals carrying null GSTM1 and GSTP1 Val/Val who received chemotherapy had lower risk of death from HCC than those without chemotherapy. 22994742 2012
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation disease BEFREE However, GSTP1 gene polymorphism is not associated with HCC risk. 23053942 2012
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification disease BEFREE Importantly, our analysis revealed an association between alcohol intake and the hypomethylation of MGMT and between hypermethylation of GSTP1 and HBV infection, indicating that hypermethylation of the genes analyzed in HCC tumors exhibits remarkably distinct patterns depending on associated risk factors. 21146512 2011
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker disease BEFREE The methylation frequencies of the ten genes examined in HCC were 40.0% for p14 ( ARF ), 60.9% for p15 ( INK4b ), 70.4% for p16 ( INK4a ), 34.8% for p73, 70.4% for GSTP1, 64.3% for MGMT, 13.0% for hMLH1, 59.1% for RARbeta, 82.6% for SOCS-1, and 80.9% for OPCML. 20112070 2010
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation disease BEFREE AG and GG alleles of GSTP1 gene polymorphisms may be considered as factors increasing the susceptibility to and risk of HCC in Taiwanese aged < or = 57 years. 20331903 2010
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 PosttranslationalModification disease BEFREE GSTP1 and/or p16(INK4a) promoter methylation was observed in 88% of the HCC samples. 18351580 2008
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 Biomarker disease BEFREE In conclusion, hypermethylation of some specific, but not all, tumor associated genes may be involved in hepatocarcinogenesis; examination of the methylation status of E-cadherin, GSTP1, P16, and RASSF1A in the plasma samples might have limited usage for HCC diagnosis. 18691570 2008
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.400 GeneticVariation disease LHGDN We conclude that the studied polymorphisms affecting GSTP1, GSTA1 and GSTM3 genes are probably not related to the risk of developing hepatocellular carcinoma in the studied population. 17716224 2007