Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Integrin alpha 7 correlates with poor clinical outcomes, and it regulates cell proliferation, apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma. 31698037 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway. 31830378 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE A treatment incorporating circ-CDYL interference and traditional enzyme inhibitors targeting PI3K and HIF1AN demonstrated highly effective inhibition of stem-like characteristics and tumor growth in HCC. 31148183 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3. 31286509 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC. 31663122 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE The PIK3 CA gene encodes the p110α protein subunit and is one of the most efficient cancer genes in solid and hematological tumors including hepatocellular carcinoma (HCC). 31668943 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE This study aims to investigate the anticancer effect of Oroxin B (OB) both in vitro and in vivo, and the molecular mechanism involved in microRNA-221 and the PI3K/Akt/PTEN pathway through modulation of apoptosis in Hepatocellular carcinoma (HCC). 31801250 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk. 31033054 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE <b>Background:</b> A recent study has revealed that miR-106b-5p might promote hepatocellular carcinoma (HCC) stemness maintenance and metastasis by targeting PTEN via PI3K/Akt pathway based on HCC cell lines and animal models.Its clinical relevance remains unknown. 31406464 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE HCC was recently shown to harbor a distinct genetic make-up and the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kiase (PI3K)/AKT signaling pathways are potential targets for anti-cancer agents in the management of recurrent HCC. 31443247 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE RosA can inhibit the proliferation and invasion of hepatocellular carcinoma cell in vitro and inhibit tumour growth in vivo and the mechanism may relate to inhibiting the activation of PI3K/AKT signal pathway. 31541884 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE Further investigations found that TFAP4 promotes invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) and regulating MMP-9 expression via activating the PI3K/AKT signaling pathway in HCC. 31281549 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 AlteredExpression disease BEFREE Gene set enrichment analysis results revealed a positive correlation between the PI3K pathway and triggering receptors expressed on myeloid cells 2 (TREM2) expression in HCC tissues. 30067868 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 GeneticVariation disease BEFREE Using PIK3CA(H1047R)/c-Met, PIK3CA(E545K)/c-Met, and sgPten/c-Met murine HCC models, we also demonstrated that deletion of Sgk3 moderately delays PIK3CA(E545K)/c-Met driven HCC, while not affecting PIK3CA(H1047R)/c-Met or sgPten/c-Met HCC formation in mice. 30975125 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Our findings revealed that MCM3 promoted radioresistance through activating NF-κB pathway, strengthening the role of MCM subunits in the tumor progression and providing a new target for HCC therapy. 31208444 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE CD73 promotes progression and metastasis through activating PI3K/AKT signaling, indicating a novel prognostic biomarker for HCC. 30971294 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE PI3K/mTOR inhibition prevented moderate heat stress-induced global effects on HCC molecular signaling and cellular function, including decreased cell survival, growth, and proliferation (Z-score, -0.3 to -3.2; <i>P</i> < .001) and increased apoptosis and cell death (Z-score, 0.4-1.1; <i>P</i> < .001).ConclusionModerate heat stress induces PI3K/mTOR/AKT-dependent global effects on hepatocellular carcinoma (HCC) cell survival, function, and death. 31335281 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Our study reveals a function of Art that induces HCC apoptosis via PI3K/AKT/mTOR pathway inhibition and suggests a potential therapeutic regimen of combination with Art and SOR against advanced HCC. 31481232 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 GeneticVariation disease BEFREE Our results unveiled that the Columbamine suppression on HCC based on the traditional medicine are clearly associated with PI3K/AKT, p38 and ERK1/2 MAPKs signaling pathways and guide further research orientation for developing the Col medicine against hepatocellular carcinoma. 30582951 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE These data confirmed that the downregulation of MARCH1 could inhibit the progression of hepatocellular carcinoma and that the mechanism may be via PI3K/AKT/β-catenin inactivation as well as the downregulation of the antiapoptotic Mcl-1/Bcl-2. 30678274 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Furthermore, the OB3 peptide inhibited phosphoinositide 3-kinase (PI3K) activation which is essential for leptin-induced proliferation in HCC. 31499123 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE The inhibition of <i>PTEN</i>  could reverse the anti-tumor action caused by the knockdown of <i>miR-367</i>  <i>MiR-367</i>  serves as an oncogene in HCC through activating the PI3K/AKT pathway by targeting <i>PTEN</i>. 31541003 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Furthermore, these findings suggest that the miR-221/AEG-1 axis plays a seminal oncogenic role by modulating PTEN/PI3K/AKT signaling pathway in HCC. 31698701 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE In addition, we observed that KLF5 could promote the epithelial-mesenchymal transition (EMT) in HCC via the PI3K/AKT/Snail signaling pathway. 30473218 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.800 Biomarker disease BEFREE Phosphatidylinositol 3-kinase (PI3K), on the other hand, has been shown to play a key role in the tumorigenesis, proliferation, metastasis, apoptosis, and angiogenesis of HCC by regulating gene expression. 30796964 2019