Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE Integrin alpha 7 correlates with poor clinical outcomes, and it regulates cell proliferation, apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma. 31698037 2020
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 AlteredExpression disease BEFREE Circ_0015756 knockdown was shown to increase the expression of miR-7, reduce the proliferation, invasion, migration and resistance to apoptosis, and down-regulate the expression of FAK in HCC. 31522588 2019
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE The present data suggest that PTK2 may be a novel prognostic biomarker for HCC recurrence, and a therapeutic target for HCC treatment. 30849480 2019
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE BI-3663 (cereblon-based) degrades PTK2 with a median DC<sub>50</sub> of 30 nM to >80% across a panel of 11 HCC cell lines. 30739444 2019
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE Additionally, high expression of both cPLA2α and p-FAK predicted the worst prognoses for HCC patients. 31516757 2019
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 AlteredExpression disease BEFREE Taken together, our data demonstrate a novel function of LOXL4 in tumor metastasis mediated by exosomes through regulation of the FAK/Src pathway and angiogenesis in HCC. 30704479 2019
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE The focal adhesion kinase (FAK) gene protein tyrosine kinase 2 is amplified in 16.4% of The Cancer Genome Atlas HCC specimens, and its amplification leads to increased FAK mRNA expression. 31069844 2019
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE Inhibition of SRC/FAK cue: A novel pathway for the synergistic effect of rosuvastatin on the anti-cancer effect of dasatinib in hepatocellular carcinoma. 30292831 2018
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE DBH-AS1 facilitated the development of HCC via miR-138/FAK/Src/ERK pathway, establishing the molecular basis of DBH-AS1 in clinical application for HCC. 30142544 2018
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE CD31 regulates metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma via the ITGB1-FAK-Akt signaling pathway. 29746931 2018
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE Mitochondrial fission promotes cell migration by Ca<sup>2+</sup> /CaMKII/ERK/FAK pathway in hepatocellular carcinoma. 29210177 2018
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE Interestingly, western blot analysis showed that treatment with oxaliplatin increased GAS7C and N-WASP protein levels and decreased the levels of proteins involved in the fibronectin/integrin/FAK pathway, such as FAK, in both HCC cell lines. 28475688 2017
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 AlteredExpression disease BEFREE In conclusion, Rab5a is overexpressed in human HCC and contributes to cancer cell proliferation and invasion through regulation of FAK and AKT signaling. 26443539 2016
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 AlteredExpression disease BEFREE Moreover, the expression levels of beta-catenin, cyclin D1, c-Myc, MMP-2, and FAK detected by western blotting were downregulated in SLC5A8-transfected HCC cells compared with control-transfected cells, indicating that SLC5A8 has a tumor-suppressive function that acts by interfering with Wnt/β-catenin signaling in HCC. 27465549 2016
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE MACC1 or combination of MACC1/FAK could serve as a novel biomarker in predicting the prognosis of HCC after LT. 24516351 2014
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE It was also shown that the combination of SKI II and U0126 further attenuated the migration of hepatoma HepG2 cells via FAK/MLC-2 signaling pathway. 23545258 2013
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE In addition, miR-151 can function synergistically with FAK to enhance HCC cell motility and spreading. 20305651 2010
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease LHGDN Focal adhesion kinase: important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells. 19082453 2009
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease RGD Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. 17203219 2007
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease LHGDN We also found that SOCS-3 physically interacted with phosphorylated FAK and Elongin B in HCC cells. 16007195 2005
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 AlteredExpression disease BEFREE We also found that the phosphorylation levels of FAK in both of the hepatoma cell lines were higher than that in L02 hepatic cells. 15532706 2004
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease LHGDN FAK proteins were detected in all HCC cell lines. 15102689 2004
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease BEFREE In conclusion, PTK2 and EIF3S3, which, respectively, encode focal adhesion kinase and the p40 subunit of the eukaryotic initiation factor 3, were probable targets within the amplification at 8q23-q24 and may be involved in progression of HCC. 14578863 2003
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.600 Biomarker disease CTD_human In conclusion, PTK2 and EIF3S3, which, respectively, encode focal adhesion kinase and the p40 subunit of the eukaryotic initiation factor 3, were probable targets within the amplification at 8q23-q24 and may be involved in progression of HCC. 14578863 2003