Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE Conclusion: This study sheds light on the tumor suppressor role of lncRNA PSTAR, a modulator of the p53 pathway, in HCC. 31148184 2020
Entrez Id: 4233
Gene Symbol: MET
MET
1.000 Biomarker disease BEFREE Twenty-two percent of advanced HCC harbored potentially druggable genetic alterations, and MET amplification was associated with complete tumor response in patients with advanced HCC treated by a specific MET inhibitor. 31206197 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE Loss of RDM1 enhances hepatocellular carcinoma progression via p53 and Ras/Raf/ERK pathways. 31670863 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 GeneticVariation disease BEFREE Advanced-stage HCC (BCLC B/C) showed higher frequencies of splicing factor 3b subunit 1 (SF3B1) (P = 0.0003), TP53 (P = 0.0006), and RB Transcriptional Corepressor 1 mutations (P = 0.03). 31206197 2020
Entrez Id: 4233
Gene Symbol: MET
MET
1.000 Biomarker disease BEFREE The hepatocyte growth factor receptor c-Met has been shown to play an important role in the pathogenesis of HCC, but the influence of c-Met expression on the clinical course of HCC remains to be fully elucidated. 31846974 2020
Entrez Id: 4233
Gene Symbol: MET
MET
1.000 Biomarker disease BEFREE STMN1 upregulation mediates HCC and hepatic stellate cells crosstalk to aggravate cancer through triggering MET pathway. 31785057 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 AlteredExpression disease BEFREE In this study, we examined mRNA expression by quantitative real-time PCR (qRT-PCR) of HOXA10 as well as histone deacetylase (HDAC) and protein levels by Western blot of HOXA10, HDAC1, Cyclin D1, proliferating cell nuclear antigen (PCNA), Survivin and p53 acetylation in HCC tissues and cell lines. 31440094 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE Furthermore, pharmacological or RNAi inhibition of the mevalonate pathway restricts the development of murine hepatocellular carcinomas driven by p53 loss. 30580964 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE Kinases have been targeted for decades with varying results, but the development of therapeutic resistance is a major challenge.<b>Areas covered</b>: The key roles of the RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1, TP53 microRNAs (miRs) as therapeutic targets are discussed and we suggests novel approaches for targeting miRs or their downstream targets to combat HCC. 31657972 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 GeneticVariation disease BEFREE In vitro, Transwell and doxorubicin (DOX)-induced apoptosis assays revealed that GSTM1 showed opposite functions in different HCC cell lines with varied TP53 genotype statuses. 31605953 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE LncRNA PLAC2 upregulates p53 to induce hepatocellular carcinoma cell apoptosis. 31233763 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE In this study, we report that the haplo-insufficient tumor suppressor ASPP2, a p53 activator, negatively regulates the mevalonate pathway to mediate its inhibitory effect on tumor growth in hepatocellular carcinoma (HCC). 31685796 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 AlteredExpression disease BEFREE Collectively, SLMP53-2 is a new mutp53-targeting agent with promising antitumor activity, particularly against HCC. 31405179 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE This study highlights the importance of FAT4 and TP53 in HCC pathogenesis and identifies new genetic variants that may have potentials for development of precise therapy for HCC. 31395065 2019
Entrez Id: 4233
Gene Symbol: MET
MET
1.000 AlteredExpression disease BEFREE Therefore, it is crucial to investigate the expression of C-MET and PD-L1, and their association with clinicopathologic factors, to facilitate the development of targeted treatments for HCC. 31186768 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE Stratifying by the expression of p53 Ser15-P (<i>P</i> = 0.016), but not by p53 (<i>P</i> = 0.301), revealed significantly different survival outcomes in patients with HCC. 30881947 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 GeneticVariation disease BEFREE It was also found that the most common p53 mutation in hepatocellular carcinomas (R249S) was a much better indicator for poor prognosis than TP53 mutations as a whole. 30542790 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 AlteredExpression disease BEFREE ASPP2 enhances chemotherapeutic sensitivity through the down-regulation of XIAP expression in a p53 independent manner in hepatocellular carcinoma. 30528232 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53. 31732712 2019
Entrez Id: 4233
Gene Symbol: MET
MET
1.000 Biomarker disease BEFREE We assessed nine single nucleotide polymorphisms (SNPs) in the FGF1, FGF2, FGF receptor (FGFR)-2, Flt-1, and c-MET genes in 245 HCC patients and 483 chronic hepatitis B virus (HBV) carriers without HCC. 30952770 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 AlteredExpression disease BEFREE The HCC-induced group showed a significant decrease in the body mass and a significant elevation in the liver weight, alpha-fetoprotein (AFP), liver enzymes, hepatic malondialdehyde (MDA), and p53 protein expression levels as well as genetic mutations in intron 5 of p53 gene in the form of Single-Nucleotide Polymorphisms (SNPs) and insertions. 31781479 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 GeneticVariation disease BEFREE TP53 mutations occurred far less frequently in our pediatric HCC cohort than reported in adult cohorts. 30977242 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 GeneticVariation disease BEFREE To test this hypothesis, the HBV integration sites and the common mutations in the TERT promoter and tumor protein P53 (TP53) coding region were analyzed in 101 HBV-related HCC cases using a capture-next-generation sequencing platform. 30070724 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE Using flow cytometry to determine cell cycle analysis and determination the possible mechanisms of action for apoptosis revealed that ME-GA arrested the cell cycle at G2/M that lead to inhibition of hepatocellular carcinoma and induced apoptosis via the extrinsic pathway and its ability to increase p53 transactivation. 30973113 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
1.000 Biomarker disease BEFREE Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type HCC, but most patients have p53-mutant tumors and intrinsic resistance to such MDM2 inhibitors. 31181320 2019