Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 140578
Gene Symbol: CHODL
CHODL
0.100 GeneticVariation disease GWASDB Genetic variants associated with disordered eating. 23568457 2013
Entrez Id: 140578
Gene Symbol: CHODL
CHODL
0.100 GeneticVariation disease GWASCAT Genetic variants associated with disordered eating. 23568457 2013
Entrez Id: 286183
Gene Symbol: NKAIN3
NKAIN3
0.100 GeneticVariation disease GWASDB Genetic variants associated with disordered eating. 23568457 2013
Entrez Id: 286183
Gene Symbol: NKAIN3
NKAIN3
0.100 GeneticVariation disease GWASCAT Genetic variants associated with disordered eating. 23568457 2013
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 GeneticVariation disease BEFREE Both models showed a nonsignificant association between the 5-HTTLPR polymorphism and BN. 22815058 2012
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 GeneticVariation disease BEFREE We evaluated the distribution of the functional 5-HTTLPR polymorphism in a series of 201 Italian, Caucasian, eating disorder patients (113 with AN and 88 with BN binge/purging (BP subtype) and in 150 Caucasian unrelated controls. 22488946 2012
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 Biomarker disease BEFREE This meta-analysis was undertaken: (1) to investigate the association between 5-HTTLPR and eating disorders considered as a whole, including anorexia (AN), bulimia (BN), and binge eating disorder (BED); (2) to extend recently reported findings on the association between 5-HTTLPR and AN-BN. 20209488 2011
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 GeneticVariation disease BEFREE We also observed a strong association between the 5HTTLPR polymorphism of the SLC6A4 gene and Anxiety in the same group of BN patients (p = 0.004). 17055531 2008
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 GeneticVariation disease BEFREE The present results are consistent with previous findings identifying a subgroup of individuals with bulimia characterized by high psychiatric comorbidity and suggest that the 5-HTTLPR polymorphism and childhood trauma may both be pertinent to explaining the presence of greater psychiatric comorbidity in bulimia-spectrum disorders. 18505306 2008
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 GeneticVariation disease BEFREE Reduced brain serotonin (5-hydroxytryptamine: 5-HT) transporter activity has been associated with susceptibility to various forms of psychopathology, including bulimia nervosa (BN) and related syndromes characterized by appetitive or behavioural dysregulation. 16407896 2006
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 GeneticVariation disease BEFREE These findings support the view that polymorphic variants of the 5HTT promoter region do not play a part in predisposing to BN, whereas they seem to predispose bulimic individuals to nutritional impairment and increased harm avoidance. 16449418 2006
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 AlteredExpression disease BEFREE A short (s) allele in the promoter region of the 5-hydroxytryptamine (5-HT) transporter gene (5HTTLPR) has been associated with low transcription of the 5-HT transporter protein, and with clinical manifestations including impulsivity, affective disorder, and bulimia nervosa. 15690467 2005
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 GeneticVariation disease LHGDN Serotonin transporter polymorphism and potential response to SSRIs in bulimia nervosa. 15940301 2005
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.100 Biomarker disease BEFREE The measurement of 5-HT1A receptors in drug-naïve schizophrenic patients using the in vivo PET methodology revealed an increase of cortical 5-HT1A receptor binding potential in schizophrenia. beta-CIT as a ligand for measurement of 5-HT transporter densities (5-HTT) revealed lower rates in depression compared to age- and sex-matching healthy controls, a measurement that has also been obtained for bulimia. 12478878 2002
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.090 PosttranslationalModification disease BEFREE We observed a significant site×group (BN vs. NE) interaction indicating that women with BN showed increases in methylation at specific regions of the BDNF promoter. 24801751 2014
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.090 GeneticVariation disease BEFREE This study: (1) assessed the role of leptin, melanocortin, and neurotrophin genetic variants in conferring risk for AN and BN; and (2) explored the involvement of these genes in body mass index (BMI) variations within AN and BN. 24831852 2014
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.090 AlteredExpression disease BEFREE Low circulating levels of BDNF are associated with a higher risk of eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). 21945389 2011
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.090 GeneticVariation disease BEFREE A DRD4/BDNF gene-gene interaction associated with maximum BMI in women with bulimia nervosa. 17922530 2008
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.090 Biomarker disease BEFREE Our data strongly suggest that altered BDNF levels modulated by BDNF gene variability are associated with the susceptibility to ED, providing physiological evidence that BDNF plays a role in the development of AN and BN, and strongly arguing for its involvement in eating behavior and body weight regulation. 17376155 2007
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.090 GeneticVariation disease BEFREE These results suggest that the 196G/A SNP of the human BDNF gene does not contribute to the genetic susceptibility to BN and BED, but may predispose those patients to a more severe binge eating behavior. 16901635 2006
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.090 Biomarker disease BEFREE Genetic studies and animal models support the participation of brain-derived neurotrophic factor (BDNF) in the vulnerability to AN and BN. 15838534 2005
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.090 Biomarker disease BEFREE Several lines of evidence support that brain-derived neurotrophic factor (BDNF) plays an essential role in eating behaviour and that alterations on this neurotrophic system participates in the susceptibility to both AN and BN. 15657604 2005
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.090 GeneticVariation disease BEFREE We have found that the Met66 variant is strongly associated to all ED subtypes (AN, ANR, binge-eating/purging AN and BN), and that the -270C BDNF variant has an effect on BN and late age at onset of weight loss. 15115760 2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.070 Biomarker disease BEFREE <b>Approach:</b> To test the hypothesis that treatment with OLB together with exercise vs. exercise alone would induce feedback action of GH, pancreatic polypeptide (PP), peptide tyrosine tyrosine (PYY), and leptin on ghrelin in Czech women with BN and in healthy-weight Czech women (HW). 30915029 2019
Entrez Id: 611
Gene Symbol: OPN1SW
OPN1SW
0.070 Biomarker disease BEFREE This suggests that bulimia nervosa may be effectively treated with CBT-T in the context of gender dysphoria. 30843609 2019