| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | AlteredExpression | disease | BEFREE | Intense GATA1 nuclear expression is a sensitive and specific marker for cells of erythroid and megakaryocytic lineages and is an excellent marker for neoplastic cells of pure erythroleukemia and acute megakaryoblastic leukemia. | 28340113 | 2017 | ||||
|
0.090 | Biomarker | disease | BEFREE | GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia. | 27010793 | 2016 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | We now report that GATA-1 directly regulates transcription of the p21 gene in both erythroleukemia cells and normal erythroid progenitors. | 20495378 | 2010 | ||||
|
0.090 | Biomarker | disease | BEFREE | Two GATA1-related leukemias have been described: one is an erythroleukemia that develops in mice as a consequence of diminished expression of wild-type GATA1, whereas the other is an acute megakaryoblastic leukemia (AMKL) that arises in Down syndrome children as a consequence of somatic N-terminal truncation (DeltaNT) of GATA1. | 19682090 | 2009 | ||||
|
0.090 | Biomarker | disease | BEFREE | GATA-1 and EPOR mRNAs were detectable in all cases of erythroleukemia (French-American-British classification: M6) or early erythroblastic leukemia. | 9808054 | 1998 | ||||
|
0.090 | Biomarker | disease | BEFREE | This analysis indicates that binding sites for the hematopoietic transcription factors NF-E2 and GATA-1 are required for the formation of the characteristic chromatin structure of the HS following stable transfection into murine erythroleukemia cells. | 7828582 | 1995 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | We found GATA-1 expression in five of five myeloid and in one megakaryocytic blast crisis of CML, in four of six cases of myelomonocytic leukemias (M4 according to FAB classification), in one case of erythroleukemia (M6), whereas lymphoid blast crisis of CML and all other FAB groups were completely negative. | 8207977 | 1994 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Downregulation of GATA-1 expression during phorbol myristate acetate-induced megakaryocytic differentiation of human erythroleukemia cells. | 8443382 | 1993 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Each of these GATA-1 sites had an enhancer activity when inserted into a reporter plasmid and tested in human erythroleukemia cells. | 2259631 | 1990 |