Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | We studied single-nucleotide polymorphisms (SNPs) in genes encoding three CCR5 ligands (CCL3 (MIP-1a), CCL4 (MIP-1b)and CCL5 (RANTES)) along with an adjacent gene encoding a CCR2ligand (CCL2 (MCP-1)) to identify candidate markers for HIV-1 infection and pathogenesis. | 21975429 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | We show that the chemokine (c-c Motif) Ligand-2 (CCL2) increases PrP(C) release from CNS cells, while HIV-1 infection alters PrP(C) release from peripheral blood mononuclear cells. | 20724601 | 2010 | ||||
|
0.080 | Biomarker | disease | BEFREE | Effect of genetic variants of CCR2 and CCL2 on the natural history of HIV-1 infection: CCL2-2518GG is overrepresented in a cohort of Spanish HIV-1-infected subjects. | 17091019 | 2007 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | These findings indicate that prednisolone suppresses both HIV-1 viral load and CCL2 mRNA expression, an association which might be exploited for future anti-inflammatory therapeutic strategies in HIV-1 infection. | 17707134 | 2007 | ||||
|
0.080 | Biomarker | disease | BEFREE | Inhibition of increased CCL2 production could provide a new therapeutic intervention in HIV-1 infection. | 16916890 | 2006 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our findings suggest that MCP-1 antagonists may be useful in HIV-1 infection, especially for HAD, and that HIV+ individuals possessing the MCP-1 -2578G allele may benefit from early initiation of antiretroviral drugs that effectively cross the blood-brain barrier. | 12374865 | 2002 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We found an increased mRNA expression of monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and RANTES by macrophages after HIV-1 infection. | 11031691 | 2000 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | In vitro, productive HIV-1 infection of monocyte-derived macrophages upregulated the secretion of MCP-1. | 9708412 | 1998 |